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CA: A Cancer Journal for Clinicians, Vol 17, 15-20, Copyright © 1967 by American Cancer Society

Chemotherapy of Malignant Lesions Unique in Children

¹ Consultant, Pediatrics Section, Mayo Clinic, Rochester, Minnesota.
² Associate Professor, Clinical Pediatrics, Mayo Clinic.

None of the chemotherapeutic agents presently used is curative in children with inoperable or metastatic neuroblastoma, Wilms' tumor, or rhabdomyosarcoma. Operative removal, when possible, still offers the best hope for cure, especially in the patient less than two years of age. With metastatic neuroblastoma, vincristine and cyclophosphamide used alternately in a monthly cycle give an increased survival time. The combined use of actinomycin D, operation, and postoperative irradiation decreases dissemination and increases survival in children with Wilms' tumor. Actinomycin D alone also causes regression of metastatic Wilms' tumor. No effective chemotherapy is available for rhabdomyosarcoma, although temporary regression follows the administration of actinomycin D, especially when its use is combined with radiation therapy.