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CA Cancer J Clin 1974; 24:258-265
doi: 10.3322/canjclin.24.5.258
© 1974 American Cancer Society
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CA: A Cancer Journal for Clinicians, Vol 24, 258-265, Copyright © 1974 by American Cancer Society

Herpes Genitalis and its Relationship to Cervical Cancer

Raymond H. Kaufman M.D.1 and William E. Rawls M.D.2

1 Professor and Ernst W. Bertner Chairman, Departments of Obstetrics and Gynecology, and Professor, Department of Pathology, Baylor College of Medicine, Houston, Texas.
2 Professor, Department of Pathology, and Director of Cancer Research Unit, McMaster University School of Medicine, Ontario, Canada.

A review of the data suggests that there is some relationship between herpesvirus type 2 and the development of cervical cancer. Indeed, recent evidence points to an even more widespread association between herpesviruses and cancer. For example, herpesvirus particles have been visualized by electron-microscopy in prostate cancer cells; viral antigens could also be detected by immunofluorescence. Antibodies to herpesvirus "nonvirion" antigens found in the sera of patients with cervical cancer have also been found in patients with other types of cancer such as squamous cell carcinoma, especially of the head and neck. While these observations are preliminary, they support the concept that herpesvirus type 2 is an etiologic agent in the development of cervical cancer, and suggest that herpesviruses types 1 and 2 may also play a ubiquitous role in the genesis of a number of other human cancers.






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Copyright © 1974 by American Cancer Society.