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CA: A Cancer Journal for Clinicians, Vol 24, 297-305, Copyright © 1974 by American Cancer Society

Temporary Remissions in Acute Leukemia in Children Produced by Folic Acid Antagonist...Aminopterin

Clinical, hematologic and histologic details of five patients with acute leukemia treated with aminopterin, selected from a group of 16 patients so treated, form the basis of this paper. It is again emphasized that these remissions are temporary in character and that the substance is toxic and may be productive of even greater disturbances than have been encountered so far in our studies. No evidence has been mentioned in this report that would justify the suggestion of the term "cure" of acute leukemia in children. A promising direction for further research concerning the nature and treatment of acute leukemia in children appears to have been established by the observations reported.