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CA: A Cancer Journal for Clinicians, Vol 29, 115-119, Copyright © 1979 by American Cancer Society

On the Frequency of Occurrence of Occult Carcinoma of the Prostate

In 292 consecutive autopsies on males 50 years or more in age dying from a wide variety of causes on the Medical, Surgical and Urological Services of the Johns Hopkins Hospital during the past three years, frank carcinoma of the prostate was [See Table 1 in Pdf Source.] found in the routine microscopical section taken at autopsy in 41 cases (14.0 percent). There is little doubt that a thorough search throughout each gland would have brought to light an even greater number of these tumors, many of which were so small that they were not seen macroscopically at the time of autopsy. The number discovered, however, indicates plainly enough that cancer of the prostate is considerably more frequent than is ordinarily supposed.

In 65.8 percent of these 41 cases the tumor was not recognized clinically, having been in most cases of a size too small to have produced symptoms or to have attracted attention on physical examination.

The tumors were most often found near the outer margins of the gland, and, even when only a few millimeters in size, showed a tendency to invade the capsule.

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