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CA Cancer J Clin 1979; 29:246-249
doi: 10.3322/canjclin.29.4.246
© 1979 American Cancer Society
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CA: A Cancer Journal for Clinicians, Vol 29, 246-249, Copyright © 1979 by American Cancer Society

Cerebellar Degeneration with Hodgkin's Disease

Gunnar Valtysson M.D.1, Paul Fisher-Beckfield M.D.2, and Paul P. Carbone M.D.3

1 House Officer IV, Department of Internal Medicine, University Hospital, Ann Arbor, Michigan.
2 The Department of Internal Medicine, University of Wisconsin Hospital, Madison, Wisconsin.
3 Professor and Chairman, Department of Human Oncology, Wisconsin Clinical Cancer Center, Madison, Wisconsin.

A 24 year old man with symptoms and signs of cerebellar degeneration for 17 months (etiology unknown) presented with a neck swelling. A biopsy revealed Hodgkin's disease. The cerebellar degeneration observed in this patient was believed to be a remote effect of his Hodgkin's disease.

The association of cerebellar degeneration and cancer is a well recognized but infrequent entity. The literature is reviewed. Only a few cases of cerebellar degeneration with Hodgkin's disease have been reported—to our knowledge, the literature contains only six cases. What is interesting about this patient is that the cerebellar symptoms preceded the diagnosis of Hodgkin's disease by a long interval. The etiology is unknown, but the possibility of viral infection or autoimmune mechanism has been studied.






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Copyright © 1979 by American Cancer Society.