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CA Cancer J Clin 1982; 32:293-300
doi: 10.3322/canjclin.32.5.293
© 1982 American Cancer Society
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CA: A Cancer Journal for Clinicians, Vol 32, 293-300, Copyright © 1982 by American Cancer Society

Virilizing Hepatoblastoma: Precocious Sexual Development and Partial Response of Pulmonary Metastases to Cis-Platinum

Raja R. Arshad M.B., B.S., Shiao Y. Woo M.D.1, Val Abbassi M.D.2, Gregory R. Hoy M.D.3, and Lucius F. Sinks M.D.4

1 Associate Professor in the Department of Pediatric Oncology/Hematology of the New England Medical Center in Boston, Massachusetts.
2 Assistant Professor in the Department of Pediatric Endocrinology of Georgetown University Medical Center in Washington, D.C.
3 Director of the Department of Pediatric Surgery of Georgetown University Medical Center in Washington, D.C.
4 Professor of Pediatrics and Chief of the Department of Pediatric Oncology/Hematology of the New England Medical Center in Boston, Massachusetts.

A 4frac23 year old boy with hepatoblastoma presented with precocious sexual development and an abdominal mass. During the course of disease, serial endocrinologic laboratory investigations were done. along with agr-fetoprotein levels. A significant correlation is noted in these values at diagnosis, postsurgery, and later during a relapse. Ectopic production of chorionic gonadotropins by the tumor is evident. After extensive surgical resection, chemotherapy was started because of metastases. Although the primary tumor failed to respond, the pulmonary metastatic disease showed a greater than 50 percent response rate with cis-platinum.






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Copyright © 1982 by American Cancer Society.