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CA Cancer J Clin 1984; 34:86-92
doi: 10.3322/canjclin.34.2.86
© 1984 American Cancer Society
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CA: A Cancer Journal for Clinicians, Vol 34, 86-92, Copyright © 1984 by American Cancer Society

Locating Pheochromocytomas by Scintigraphy Using 131I-Metaiodobenzylguanidine

James C. Sisson M.D.1, Brahm Shapiro M.B., Ch.B., Ph.D.2, William H. Beierwaltes M.D.3, and Jeanne E. Copp M.P.H.4

1 Professor of Internal Medicine in the Nuclear Medicine Division of The University of Michigan Hospitals in Ann Arbor, Michigan.
2 Associate Professor of Internal Medicine in the Nuclear Medicine Division of The University of Michigan Hospitals in Ann Arbor, Michigan.
3 Professor of Internal Medicine and Head of the Nuclear Medicine Division of The University of Michigan Hospitals in Ann Arbor, Michigan.
4 Biostatistician in the Nuclear Medicine Division of The University of Michigan Hospitals in Ann Arbor, Michigan.

Scintigraphy with 131I-MIBG has located most pheochromocytomas. The detected tumors have been intra-adrenal, extra-adrenal, malignant, and familial in type. The method is safe, but requires images taken over three days to attain optimal results. Because of its ability to screen all sites where primary pheochromocytomas may reside, scintigraphy should be employed as the initial procedure in the search for these tumors. It may be the only technique that will locate extra-adrenal pheochromocytomas. The rate of false-negative results is about 10 percent; therefore, other technique such as computed tomography will be necessary to help find the few elusive pheochromocytomas.






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Copyright © 1984 by American Cancer Society.