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CA: A Cancer Journal for Clinicians, Vol 36, 322-350, Copyright © 1986 by American Cancer Society

Current Therapy of Acute and Chronic Leukemia in Adults

¹ Chief of Medical Oncology at Roswell Park Memorial Institute in Buffalo, New York.
² Associate Chief of Medical Oncology at Roswell Park Memorial Institute in Buffalo, New York.

Leukemia treatments to date have exploited, often successfully, the limited specificity of cytotoxic chemotherapy and the remarkable ability of normal bone marrow to regenerate after major injury. During the last decade, remarkable advances in molecular biology have not only demonstrated leukemia-related genetic abnormalities, but have shed light on how cells initiate and control cell repletion and differentiation. Biochemical pharmacologists and immunologists have been quick to respond to these leads and to design new probes and agents that might detect and destroy leukemic cells. Such agents should ultimately prove effective in correcting the basic pathology of leukemia tissue by eliminating the arrest and accumulation of cells at a level of suboptimal function, and inducing permanent restoration of normally regulated hemopoiesis.