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CA Cancer J Clin 1988; 38:280-290
doi: 10.3322/canjclin.38.5.280
© 1988 American Cancer Society
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CA: A Cancer Journal for Clinicians, Vol 38, 280-290, Copyright © 1988 by American Cancer Society

Virus Interference: I. The Interferon

Alick Isaacs and Jean Lindenmann 1

1 Professor and Director of the Institute for Immunology and Virology at the University of Zürich in Zürich, Switzerland.

During a study of the intetference produced by heat-inactivated influenza virus with the growth of live virus in fragments of chick chorio-allantoic membrane, it was found that following incubation of heated virus with membrane a new factor was released. This factor, recognized by its ability to induce interference in fresh pieces of chorio-allantoic membrane, was called interferon. Following a lag phase interferon was first detected in the membranes after three hours of incubation, and thereafter it was released into the surrounding fluid.






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Copyright © 1988 by American Cancer Society.