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CA: A Cancer Journal for Clinicians, Vol 39, 50-57, Copyright © 1989 by American Cancer Society

The Use of Cancer Registry Data to Study Preoperative Carcinoembryonic Antigen Level as an Indicator of Survival in Colorectal Cancer

¹ Attending Surgeon at Evanston Hospital in Evanston, Illinois, and Assistant Professor of Clinical Surgery at Northwestern University Medical School in Chicago, Illinois.
² Attending Physician in Radiation Oncology at Evanston Hospital in Evanston, Illinois, and Assistant Professor (Clinical) of Radiology at Northwestern University Medical School in Chicago, Illinois.
³ Associate Professor in the Department of Community Health and Preventive Medicine at Northwestern University Medical School in Chicago, Illinois.
⁴ Managing Editor of the Cancer Incidence and End Results Committee of the Illinois Division of the American Cancer Society in Chicago, Illinois.
⁵ Director of Prevention and Early Detection of the Illinois Division of the American Cancer Society in Chicago, Illinois.

A retrospective analysis of survival results for colorectal cancer patients in Illinois was performed by the Cancer Incidence and End Results Committee of the Illinois Division of the American Cancer Society. Cancer registry data on 1,774 patients from 63 hospitals were used to investigate whether the preoperative level of serum carcinoembrvonic antigen (CEA) was a prognostic indicator of survival for cancers diagnosed between 1976 and 1978.

A direct relationship was found between the preoperative level of serum CEA and both the thickness and stage of the tumor at initial diagnosis. For Stage B2/3 colorectal cancer, the actuarial survival curves corresponding to normal, elevated, and markedly elevated CEA levels were significantly different (p < 0.0001). The five-year survival rates for these patients were 61. 50, and 32 percent, respectively. Similar trends for patients with Stage C2/3 cancer were observed (p = 0.0058). The corresponding five-year survival rates were 44, 30, and 26 percent, respectively.

Using a statewide cancer registry system, the analysis suggested that the pre-operative level of serum CEA was an indicator of survival in patients with colorectal cancer, independent of the stage of disease at diagnosis.

This article has been cited by other articles:

				Y.-A. Park, K. Y. Lee, N. K. Kim, S. H. Baik, S. K. Sohn, and C. W. Cho Prognostic Effect of Perioperative Change of Serum Carcinoembryonic Antigen Level: A Useful Tool for Detection of Systemic Recurrence in Rectal Cancer Ann. Surg. Oncol., May 1, 2006; 13(5): 645 - 650. [Abstract] [Full Text] [PDF]