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CA: A Cancer Journal for Clinicians, Vol 39, 179-192, Copyright © 1989 by American Cancer Society

Precursors of Corpus Carcinoma Estrogens and Adenomatous Hyperplasia

¹ Distinguished Service Professor for that institution and Consultant to the Department of Medical Affairs for the American Cancer Society in New York, New York.

1. A pattern of adenomatous hyperplasia of the endometrium is described which bears a constant relation to estrogen stimulation in both benign and malignant tissues.

2. We have presented data concerning this endocrine-tumor relationship in four related groups: (a) Endometrial hyperplasia produced by granulosa cell tumors. (b) Endometrial hyperplasia produced by prolonged estrogen administration. (c) Endometrial adenocarcinoma arising in patients receiving prolonged estrogen administration. (d) Endometrial patterns in patients with recurrent episodes of "functional bleeding."

3. The well-defined histologic pattern recurring in these related groups of tissues suggests that endogenous or exogenous estrogens play a role in the development of corpus carcinoma. We have called attention to a type of endometrial hyperplasia which is a cancer precursor.