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CA Cancer J Clin 1994; 44:160
doi: 10.3322/canjclin.44.3.160
© 1994 American Cancer Society
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CA: A Cancer Journal for Clinicians, Vol 44, Issue 3 160-170, Copyright © 1994 by American Cancer Society

ARTICLES

Oncogenes and tumor suppressor genes

R. A. Weinberg
Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology in Cambridge, USA.

In the past 15 years, many of the mechanisms underlying the molecular origins of cancer have been uncovered, and a clear picture of the role of oncogenes and tumor suppressor genes in carcinogenesis has developed. This article reviews the mechanisms by which oncogenes and tumor suppressor genes participate in the creation of tumors.


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Copyright © 1994 by American Cancer Society.