HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE COVER ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Submit a letter to the editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Jessup, J. M. Articles by Winchester, D. P. Search for Related Content PubMed PubMed Citation Articles by Jessup, J. M. Articles by Winchester, D. P.

CA: A Cancer Journal for Clinicians, Vol 47, Issue 2 70-92, Copyright © 1997 by American Cancer Society

ARTICLES

Diagnosing colorectal carcinoma: clinical and molecular approaches

J. M. Jessup, H. R. Menck, A. Fremgen and D. P. Winchester
Department of Surgery at New England Deaconess Hospital, Boston, Massachusetts, USA.

In summary, the ability to decrease the mortality of colorectal carcinoma is increasingly within the grasp of clinicians. With accurate family and personal history, it is possible to estimate the risk of colorectal cancer and initiate FOBT and colonoscopy where appropriate. In the future, germline and even somatic genetic testing will further increase our ability to diagnose cancers before they become widely invasive. As molecular biology unravels the cause of what currently appears to be the majority of sporadic cancers, it may be possible to characterize more colorectal cancers that are caused by novel, as yet not recognized mutator genes. Unfortunately, a set of patients is likely to exist who remain to be diagnosed by symptoms caused by advanced cancer. The goal for the clinician is to decrease this subset to as small a group as possible.

This article has been cited by other articles:

				G. Ercolani, G. L. Grazi, M. Ravaioli, M. Cescon, A. Gardini, G. Varotti, M. Del Gaudio, B. Nardo, and A. Cavallari Liver Resection for Multiple Colorectal Metastases: Influence of Parenchymal Involvement and Total Tumor Volume, vs Number or Location, on Long-term Survival Arch Surg, October 1, 2002; 137(10): 1187 - 1192. [Abstract] [Full Text] [PDF]