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CA: A Cancer Journal for Clinicians, Vol 50, Issue 6 349-375, Copyright © 2000 by American Cancer Society

ARTICLES

External beam radiation therapy for prostate cancer

E. M. Horwitz and G. E. Hanks
Department of Radiation Oncology at Fox Chase Cancer Center, Philadelphia, PA, USA.

Men with non-metastatic prostate cancer have many treatment options. For over 35 years, radiation therapy has been a mainstay of treatment for this disease. With improvements in technology and better use of pretreatment prognostic factors, such as prostate specific antigen level and Gleason score, biochemical and clinical results have steadily improved. This article reviews the current status of radiation therapy in the treatment of prostate cancer. Results of treatment utilizing three-dimensional conformal and conventional techniques are compared and contrasted. The appropriate use of adjuvant hormones and particle beam therapy in the management of this disease is also discussed. Finally, the toxicity and future directions of radiation therapy in the treatment of prostate cancer are addressed.