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Dr. Parkin is Chief, Unit of Descriptive Epidemiology, International Agency for Research on Cancer, Lyon, France.
Mr. Bray is Epidemiologist, Unit of Descriptive Epidemiology, International Agency for Research on Cancer, Lyon, France.
Mr. Ferlay is Informatics Officer, Unit of Descriptive Epidemiology, International Agency for Research on Cancer, Lyon, France.
Dr. Pisani is Scientist, Unit of Descriptive Epidemiology, International Agency for Research on Cancer, Lyon, France.
Estimates of the worldwide incidence, mortality and prevalence of 26 cancers in the year 2002 are now available in the GLOBOCAN series of the International Agency for Research on Cancer. The results are presented here in summary form, including the geographic variation between 20 large "areas" of the world. Overall, there were 10.9 million new cases, 6.7 million deaths, and 24.6 million persons alive with cancer (within three years of diagnosis). The most commonly diagnosed cancers are lung (1.35 million), breast (1.15 million), and colorectal (1 million); the most common causes of cancer death are lung cancer (1.18 million deaths), stomach cancer (700,000 deaths), and liver cancer (598,000 deaths). The most prevalent cancer in the world is breast cancer (4.4 million survivors up to 5 years following diagnosis). There are striking variations in the risk of different cancers by geographic area. Most of the international variation is due to exposure to known or suspected risk factors related to lifestyle or environment, and provides a clear challenge to prevention.
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 E. Kenne Sarenmalm, A.-L. Thoren-Jonsson, F. Gaston-Johansson, and J. Ohlen Making Sense of Living Under the Shadow of Death: Adjusting to a Recurrent Breast Cancer Illness Qual Health Res, August 1, 2009; 19(8): 1116 - 1130. [Abstract] [PDF]
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 G. Corso, C. Pedrazzani, D. Marrelli, V. Pascale, E. Pinto, and F. Roviello Correlation of Microsatellite Instability at Multiple Loci With Long-term Survival in Advanced Gastric Carcinoma Arch Surg, August 1, 2009; 144(8): 722 - 727. [Abstract] [Full Text] [PDF]
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T. S. Dabakuyo, J. Fraisse, S. Causeret, S. Gouy, M.-M. Padeano, C. Loustalot, J. Cuisenier, J.-M. Sauzedde, M. Smail, J.-P. Combier, et al. A multicenter cohort study to compare quality of life in breast cancer patients according to sentinel lymph node biopsy or axillary lymph node dissection Ann. Onc., August 1, 2009; 20(8): 1352 - 1361. [Abstract] [Full Text] [PDF]
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J. Zabaleta, L. J. Su, H.-Y. Lin, R. A. Sierra, M. C. Hall, A. O. Sartor, P. E. Clark, J. J. Hu, and A. C. Ochoa Cytokine genetic polymorphisms and prostate cancer aggressiveness Carcinogenesis, August 1, 2009; 30(8): 1358 - 1362. [Abstract] [Full Text] [PDF]
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J. O. Lee, K. W. Lee, D. Y. Oh, J. H. Kim, S. A. Im, T. Y. Kim, and Y. J. Bang Combination chemotherapy with capecitabine and cisplatin for patients with metastatic hepatocellular carcinoma Ann. Onc., August 1, 2009; 20(8): 1402 - 1407. [Abstract] [Full Text] [PDF]
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K. CHARALABOPOULOS, A. KOTSALOS, A. BATISTATOU, A. CHARALABOPOULOS, D. PESCHOS, P. VEZYRAKI, V. KALFAKAKOU, A. METSIOS, A. CHARALAMPOPOULOS, A. MACHERAS, et al. Serum and Tissue Selenium Levels in Gastric Cancer Patients and Correlation with CEA Anticancer Res, August 1, 2009; 29(8): 3465 - 3467. [Abstract] [Full Text] [PDF]
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R. D. Pylypchuk, L. J. Schouten, R. A. Goldbohm, H. C. Schouten, and P. A. van den Brandt Body Mass Index, Height, and Risk of Lymphatic Malignancies: A Prospective Cohort Study Am. J. Epidemiol., August 1, 2009; 170(3): 297 - 307. [Abstract] [Full Text] [PDF]
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 A. P. Martin, M. A. Park, C. Mitchell, T. Walker, M. Rahmani, A. Thorburn, D. Haussinger, R. Reinehr, S. Grant, and P. Dent BCL-2 Family Inhibitors Enhance Histone Deacetylase Inhibitor and Sorafenib Lethality via Autophagy and Overcome Blockade of the Extrinsic Pathway to Facilitate Killing Mol. Pharmacol., August 1, 2009; 76(2): 327 - 341. [Abstract] [Full Text] [PDF]
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T. Walker, C. Mitchell, M. A. Park, A. Yacoub, M. Graf, M. Rahmani, P. J. Houghton, C. Voelkel-Johnson, S. Grant, and P. Dent Sorafenib and Vorinostat Kill Colon Cancer Cells by CD95-Dependent and -Independent Mechanisms Mol. Pharmacol., August 1, 2009; 76(2): 342 - 355. [Abstract] [Full Text] [PDF]
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D. A. Zaharoff, B. S. Hoffman, H. B. Hooper, C. J. Benjamin Jr., K. K. Khurana, K. W. Hance, C. J. Rogers, P. A. Pinto, J. Schlom, and J. W. Greiner Intravesical Immunotherapy of Superficial Bladder Cancer with Chitosan/Interleukin-12 Cancer Res., August 1, 2009; 69(15): 6192 - 6199. [Abstract] [Full Text] [PDF]
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 R. Sinha, S. Devesa, T. Rastogi, and A. Mathew Author's response Int. J. Epidemiol., August 1, 2009; 38(4): 1158 - 1159. [Full Text] [PDF]
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T. Toyoda, T. Tsukamoto, S. Takasu, N. Hirano, H. Ban, L. Shi, T. Kumagai, T. Tanaka, and M. Tatematsu Pitavastatin Fails to Lower Serum Lipid Levels or Inhibit Gastric Carcinogenesis in Helicobacter pylori-Infected Rodent Models Cancer Prevention Research, August 1, 2009; 2(8): 751 - 758. [Abstract] [Full Text] [PDF]
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 C.-Y. Chen, Y.-T. Kuo, C.-H. Lee, T.-J. Hsieh, C.-M. Jan, T.-S. Jaw, W.-T. Huang, and F.-J. Yu Differentiation between Malignant and Benign Gastric Ulcers: CT Virtual Gastroscopy versus Optical Gastroendoscopy Radiology, August 1, 2009; 252(2): 410 - 417. [Abstract] [Full Text] [PDF]
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G. Lurje, H. Husain, D. G. Power, D. Yang, S. Groshen, A. Pohl, W. Zhang, Y. Ning, P. C. Manegold, A. El-Khoueiry, et al. Genetic variations in angiogenesis pathway genes associated with clinical outcome in localized gastric adenocarcinoma Ann. Onc., July 24, 2009; (2009) mdp280v2. [Abstract] [Full Text] [PDF]
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Y. Kataoka, T. Mukohara, H. Shimada, N. Saijo, M. Hirai, and H. Minami Association between gain-of-function mutations in PIK3CA and resistance to HER2-targeted agents in HER2-amplified breast cancer cell lines Ann. Onc., July 24, 2009; (2009) mdp304v1. [Abstract] [Full Text] [PDF]
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 L. Fuccio, R. M. Zagari, L. H. Eusebi, L. Laterza, V. Cennamo, L. Ceroni, D. Grilli, and F. Bazzoli Meta-analysis: Can Helicobacter pylori Eradication Treatment Reduce the Risk for Gastric Cancer? Ann Intern Med, July 21, 2009; 151(2): 121 - 128. [Abstract] [Full Text] [PDF]
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M. Seike, A. Goto, T. Okano, E. D. Bowman, A. J. Schetter, I. Horikawa, E. A. Mathe, J. Jen, P. Yang, H. Sugimura, et al. MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers PNAS, July 21, 2009; 106(29): 12085 - 12090. [Abstract] [Full Text] [PDF]
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A. Thiel, A. Ganesan, J. Mrena, S. Junnila, A. Nykanen, A. Hemmes, H.-H. Tai, O. Monni, A. Kokkola, C. Haglund, et al. 15-Hydroxyprostaglandin Dehydrogenase Is Down-regulated in Gastric Cancer Clin. Cancer Res., July 15, 2009; 15(14): 4572 - 4580. [Abstract] [Full Text] [PDF]
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 N. Garcia-Sierra, E. Martro, E. Castella, M. Llatjos, A. Tarrats, E. Bascunana, R. Diaz, M. Carrasco, G. Sirera, L. Matas, et al. Evaluation of an Array-Based Method for Human Papillomavirus Detection and Genotyping in Comparison with Conventional Methods Used in Cervical Cancer Screening J. Clin. Microbiol., July 1, 2009; 47(7): 2165 - 2169. [Abstract] [Full Text] [PDF]
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T. Andre, C. Boni, M. Navarro, J. Tabernero, T. Hickish, C. Topham, A. Bonetti, P. Clingan, J. Bridgewater, F. Rivera, et al. Improved Overall Survival With Oxaliplatin, Fluorouracil, and Leucovorin As Adjuvant Treatment in Stage II or III Colon Cancer in the MOSAIC Trial J. Clin. Oncol., July 1, 2009; 27(19): 3109 - 3116. [Abstract] [Full Text] [PDF]
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E. Van Cutsem, R. Labianca, G. Bodoky, C. Barone, E. Aranda, B. Nordlinger, C. Topham, J. Tabernero, T. Andre, A. F. Sobrero, et al. Randomized Phase III Trial Comparing Biweekly Infusional Fluorouracil/Leucovorin Alone or With Irinotecan in the Adjuvant Treatment of Stage III Colon Cancer: PETACC-3 J. Clin. Oncol., July 1, 2009; 27(19): 3117 - 3125. [Abstract] [Full Text] [PDF]
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D. Planchard, J. Domont, E. Taranchon, I. Monnet, J. Tredaniel, R. Caliandro, P. Validire, B. Besse, J.-C. Soria, and P. Fouret The NER proteins are differentially expressed in ever smokers and in never smokers with lung adenocarcinoma Ann. Onc., July 1, 2009; 20(7): 1257 - 1263. [Abstract] [Full Text] [PDF]
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M. Tessema, Y. Y. Yu, C. A. Stidley, E. O. Machida, K. E. Schuebel, S. B. Baylin, and S. A. Belinsky Concomitant promoter methylation of multiple genes in lung adenocarcinomas from current, former and never smokers Carcinogenesis, July 1, 2009; 30(7): 1132 - 1138. [Abstract] [Full Text] [PDF]
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