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Dr. Parkin is Chief, Unit of Descriptive Epidemiology, International Agency for Research on Cancer, Lyon, France.
Mr. Bray is Epidemiologist, Unit of Descriptive Epidemiology, International Agency for Research on Cancer, Lyon, France.
Mr. Ferlay is Informatics Officer, Unit of Descriptive Epidemiology, International Agency for Research on Cancer, Lyon, France.
Dr. Pisani is Scientist, Unit of Descriptive Epidemiology, International Agency for Research on Cancer, Lyon, France.
Estimates of the worldwide incidence, mortality and prevalence of 26 cancers in the year 2002 are now available in the GLOBOCAN series of the International Agency for Research on Cancer. The results are presented here in summary form, including the geographic variation between 20 large "areas" of the world. Overall, there were 10.9 million new cases, 6.7 million deaths, and 24.6 million persons alive with cancer (within three years of diagnosis). The most commonly diagnosed cancers are lung (1.35 million), breast (1.15 million), and colorectal (1 million); the most common causes of cancer death are lung cancer (1.18 million deaths), stomach cancer (700,000 deaths), and liver cancer (598,000 deaths). The most prevalent cancer in the world is breast cancer (4.4 million survivors up to 5 years following diagnosis). There are striking variations in the risk of different cancers by geographic area. Most of the international variation is due to exposure to known or suspected risk factors related to lifestyle or environment, and provides a clear challenge to prevention.
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S. Afzal, S. A. Jensen, B. Vainer, U. Vogel, J. P. Matsen, J. B. Sorensen, P. K. Andersen, and H. E. Poulsen MTHFR polymorphisms and 5-FU-based adjuvant chemotherapy in colorectal cancer Ann. Onc., October 1, 2009; 20(10): 1660 - 1666. [Abstract] [Full Text] [PDF]
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 S. B. Park, C. S.-Y. Lin, A. V. Krishnan, D. Goldstein, M. L. Friedlander, and M. C. Kiernan Oxaliplatin-induced neurotoxicity: changes in axonal excitability precede development of neuropathy Brain, October 1, 2009; 132(10): 2712 - 2723. [Abstract] [Full Text] [PDF]
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L. Zhao, B. Y. Lee, D. A. Brown, M. P. Molloy, G. M. Marx, N. Pavlakis, M. J. Boyer, M. R. Stockler, W. Kaplan, S. N. Breit, et al. Identification of Candidate Biomarkers of Therapeutic Response to Docetaxel by Proteomic Profiling Cancer Res., October 1, 2009; 69(19): 7696 - 7703. [Abstract] [Full Text] [PDF]
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S. AL-SAAD, T. DONNEM, K. AL-SHIBLI, M. PERSSON, R. M. BREMNES, and L.-T. BUSUND Diverse Prognostic Roles of Akt Isoforms, PTEN and PI3K in Tumor Epithelial Cells and Stromal Compartment in Non-small Cell Lung Cancer Anticancer Res, October 1, 2009; 29(10): 4175 - 4183. [Abstract] [Full Text] [PDF]
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K. YAMAMOTO, Y. FUJIWARA, T. NISHIDA, S. TAKIGUCHI, K. NAKAJIMA, H. MIYATA, M. YAMASAKI, M. MORI, and Y. DOKI Induction Chemotherapy with Docetaxel, 5-FU and CDDP (DFP) for Advanced Gastric Cancer Anticancer Res, October 1, 2009; 29(10): 4211 - 4215. [Abstract] [Full Text] [PDF]
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 S. M. Hussain, C. Reinhold, and D. G. Mitchell Cirrhosis and Lesion Characterization at MR Imaging RadioGraphics, October 1, 2009; 29(6): 1637 - 1652. [Abstract] [Full Text] [PDF]
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 S.-i. Akaboshi, S. Watanabe, Y. Hino, Y. Sekita, Y. Xi, K. Araki, K.-i. Yamamura, M. Oshima, T. Ito, H. Baba, et al. HMGA1 Is Induced by Wnt/{beta}-Catenin Pathway and Maintains Cell Proliferation in Gastric Cancer Am. J. Pathol., October 1, 2009; 175(4): 1675 - 1685. [Abstract] [Full Text] [PDF]
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E. A. Mathe, G. H. Nguyen, E. D. Bowman, Y. Zhao, A. Budhu, A. J. Schetter, R. Braun, M. Reimers, K. Kumamoto, D. Hughes, et al. MicroRNA Expression in Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus: Associations with Survival Clin. Cancer Res., October 1, 2009; 15(19): 6192 - 6200. [Abstract] [Full Text] [PDF]
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J. R Stark, L. Mucci, K. J Rothman, and H.-O. Adami Screening for prostate cancer remains controversial BMJ, September 24, 2009; 339(sep24_1): b3601 - b3601. [Full Text]
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G. Giaccone, P. Zatloukal, J. Roubec, K. Floor, J. Musil, M. Kuta, R. J. van Klaveren, S. Chaudhary, A. Gunther, and S. Shamsili Multicenter Phase II Trial of YM155, a Small-Molecule Suppressor of Survivin, in Patients With Advanced, Refractory, Non-Small-Cell Lung Cancer J. Clin. Oncol., September 20, 2009; 27(27): 4481 - 4486. [Abstract] [Full Text] [PDF]
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T. Nagasaka, N. Tanaka, H. M. Cullings, D.-S. Sun, H. Sasamoto, T. Uchida, M. Koi, N. Nishida, Y. Naomoto, C. R. Boland, et al. Analysis of Fecal DNA Methylation to Detect Gastrointestinal Neoplasia J Natl Cancer Inst, September 16, 2009; 101(18): 1244 - 1258. [Abstract] [Full Text] [PDF]
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T. Naganuma, S. Kuriyama, M. Kakizaki, T. Sone, N. Nakaya, K. Ohmori-Matsuda, A. Hozawa, Y. Nishino, and I. Tsuji Green Tea Consumption and Hematologic Malignancies in Japan: The Ohsaki Study Am. J. Epidemiol., September 15, 2009; 170(6): 730 - 738. [Abstract] [Full Text] [PDF]
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 G. B. W. Wertheim, T. W. Yang, T.-c. Pan, A. Ramne, Z. Liu, H. P. Gardner, K. D. Dugan, P. Kristel, B. Kreike, M. J. van de Vijver, et al. The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis PNAS, September 15, 2009; 106(37): 15855 - 15860. [Abstract] [Full Text] [PDF]
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H. Yang, J. Gu, K. K. Wang, W. Zhang, J. Xing, Z. Chen, J. A. Ajani, and X. Wu MicroRNA Expression Signatures in Barrett's Esophagus and Esophageal Adenocarcinoma Clin. Cancer Res., September 15, 2009; 15(18): 5744 - 5752. [Abstract] [Full Text] [PDF]
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 S. Ma, Y. Yang, C. Wang, N. Hui, L. Gu, H. Zhong, Z. Cai, Q. Wang, Q. Zhang, N. Li, et al. Endogenous Human CaMKII Inhibitory Protein Suppresses Tumor Growth by Inducing Cell Cycle Arrest and Apoptosis through Down-regulation of the Phosphatidylinositide 3-Kinase/Akt/HDM2 Pathway J. Biol. Chem., September 11, 2009; 284(37): 24773 - 24782. [Abstract] [Full Text] [PDF]
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B. Holm, A. Mellemgaard, T. Skov, and B. G. Skov Different Impact of Excision Repair Cross-Complementation Group 1 on Survival in Male and Female Patients With Inoperable Non-Small-Cell Lung Cancer Treated With Carboplatin and Gemcitabine J. Clin. Oncol., September 10, 2009; 27(26): 4254 - 4259. [Abstract] [Full Text] [PDF]
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M. J. Duffy, C. Sturgeon, R. Lamerz, C. Haglund, V. L. Holubec, R. Klapdor, A. Nicolini, O. Topolcan, and V. Heinemann Tumor markers in pancreatic cancer: a European Group on Tumor Markers (EGTM) status report Ann. Onc., September 8, 2009; (2009) mdp332v2. [Abstract] [Full Text] [PDF]
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 P. Massoner, D. Colleselli, A. Matscheski, H. Pircher, S. Geley, P. Jansen Durr, and H. Klocker Novel mechanism of IGF-binding protein-3 action on prostate cancer cells: inhibition of proliferation, adhesion, and motility Endocr. Relat. Cancer, September 1, 2009; 16(3): 795 - 808. [Abstract] [Full Text] [PDF]
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B. Escudier, J. Roigas, S. Gillessen, U. Harmenberg, S. Srinivas, S. F. Mulder, G. Fountzilas, C. Peschel, P. Flodgren, E. C. Maneval, et al. Phase II Study of Sunitinib Administered in a Continuous Once-Daily Dosing Regimen in Patients With Cytokine-Refractory Metastatic Renal Cell Carcinoma J. Clin. Oncol., September 1, 2009; 27(25): 4068 - 4075. [Abstract] [Full Text] [PDF]
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G. A. van Hazel, N. Pavlakis, D. Goldstein, I. N. Olver, M. J. Tapner, D. Price, G. D. Bower, G. M. Briggs, M. A. Rossleigh, D. J. Taylor, et al. Treatment of Fluorouracil-Refractory Patients With Liver Metastases From Colorectal Cancer by Using Yttrium-90 Resin Microspheres Plus Concomitant Systemic Irinotecan Chemotherapy J. Clin. Oncol., September 1, 2009; 27(25): 4089 - 4095. [Abstract] [Full Text] [PDF]
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N. Houssami, S. Ciatto, F. Martinelli, R. Bonardi, and S. W. Duffy Early detection of second breast cancers improves prognosis in breast cancer survivors Ann. Onc., September 1, 2009; 20(9): 1505 - 1510. [Abstract] [Full Text] [PDF]
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J.-Y. Lee, A. K. Park, K.-M. Lee, S. K. Park, S. Han, W. Han, D.-Y. Noh, K.-Y. Yoo, H. Kim, S. J. Chanock, et al. Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women Carcinogenesis, September 1, 2009; 30(9): 1528 - 1531. [Abstract] [Full Text] [PDF]
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 S. Y. Kim, H. K. Ha, S. W. Park, J. Kang, K. W. Kim, S. S. Lee, S. H. Park, and A. Y. Kim Gastrointestinal Metastasis From Primary Lung Cancer: CT Findings and Clinicopathologic Features Am. J. Roentgenol., September 1, 2009; 193(3): W197 - W201. [Abstract] [Full Text] [PDF]
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