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CA Cancer J Clin 2005; 55:74-108
doi: 10.3322/canjclin.55.2.74
© 2005 American Cancer Society
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Global Cancer Statistics, 2002

D. Max Parkin, MD, Freddie Bray, J. Ferlay and Paola Pisani, PhD


Dr. Parkin is Chief, Unit of Descriptive Epidemiology, International Agency for Research on Cancer, Lyon, France.
Mr. Bray is Epidemiologist, Unit of Descriptive Epidemiology, International Agency for Research on Cancer, Lyon, France.
Mr. Ferlay is Informatics Officer, Unit of Descriptive Epidemiology, International Agency for Research on Cancer, Lyon, France.
Dr. Pisani is Scientist, Unit of Descriptive Epidemiology, International Agency for Research on Cancer, Lyon, France.

Estimates of the worldwide incidence, mortality and prevalence of 26 cancers in the year 2002 are now available in the GLOBOCAN series of the International Agency for Research on Cancer. The results are presented here in summary form, including the geographic variation between 20 large "areas" of the world. Overall, there were 10.9 million new cases, 6.7 million deaths, and 24.6 million persons alive with cancer (within three years of diagnosis). The most commonly diagnosed cancers are lung (1.35 million), breast (1.15 million), and colorectal (1 million); the most common causes of cancer death are lung cancer (1.18 million deaths), stomach cancer (700,000 deaths), and liver cancer (598,000 deaths). The most prevalent cancer in the world is breast cancer (4.4 million survivors up to 5 years following diagnosis). There are striking variations in the risk of different cancers by geographic area. Most of the international variation is due to exposure to known or suspected risk factors related to lifestyle or environment, and provides a clear challenge to prevention.




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Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma
PNAS, May 4, 2010; 107(18): 8357 - 8362.
[Abstract] [Full Text] [PDF]


Home page
Cancer Epidemiol. Biomarkers Prev.Home page
S. C. Chuang, Y. C. A. Lee, M. Hashibe, M. Dai, T. Zheng, and P. Boffetta
Interaction between Cigarette Smoking and Hepatitis B and C Virus Infection on the Risk of Liver Cancer: A Meta-analysis
Cancer Epidemiol. Biomarkers Prev., May 1, 2010; 19(5): 1261 - 1268.
[Abstract] [Full Text] [PDF]


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Hum Exp ToxicolHome page
J. S. Yang, C. C. Wu, C. L. Kuo, C. C. Yeh, F. S. Chueh, C. K. Hsu, C. K. Wang, C. Y. Chang, S. W. Ip, Y. M. Hsu, et al.
Solannm lyratum extract affected immune response in normal and leukemia murine animal in vivo
Human and Experimental Toxicology, May 1, 2010; 29(5): 359 - 367.
[Abstract] [PDF]


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Am. J. Clin. Nutr.Home page
J. Kim, S. Park, and B. H. Nam
Gastric cancer and salt preference: a population-based cohort study in Korea
Am. J. Clinical Nutrition, May 1, 2010; 91(5): 1289 - 1293.
[Abstract] [Full Text] [PDF]


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Arch Otolaryngol Head Neck SurgHome page
C. Torre, S. J. Wang, W. Xia, and L. Y. W. Bourguignon
Reduction of Hyaluronan-CD44-Mediated Growth, Migration, and Cisplatin Resistance in Head and Neck Cancer Due to Inhibition of Rho Kinase and PI-3 Kinase Signaling
Arch Otolaryngol Head Neck Surg, May 1, 2010; 136(5): 493 - 501.
[Abstract] [Full Text] [PDF]


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Ann OncolHome page
B. Glimelius, M. Lahn, S. Gawande, A. Cleverly, C. Darstein, L. Musib, Y. Liu, K. L. Spindler, J. E. Frodin, A. Berglund, et al.
A window of opportunity phase II study of enzastaurin in chemonaive patients with asymptomatic metastatic colorectal cancer
Ann. Onc., May 1, 2010; 21(5): 1020 - 1026.
[Abstract] [Full Text] [PDF]


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J. Mol. Diagn.Home page
P. Schatz, D. Dietrich, T. Koenig, M. Burger, A. Lukas, I. Fuhrmann, G. Kristiansen, R. Stoehr, M. Schuster, R. Lesche, et al.
Development of a Diagnostic Microarray Assay to Assess the Risk of Recurrence of Prostate Cancer Based on PITX2 DNA Methylation
J. Mol. Diagn., May 1, 2010; 12(3): 345 - 353.
[Abstract] [Full Text] [PDF]


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Am. J. Roentgenol.Home page
M. W. Lee, Y. J. Kim, H. S. Park, N. C. Yu, S. I. Jung, S. Y. Ko, and H. J. Jeon
Targeted Sonography for Small Hepatocellular Carcinoma Discovered by CT or MRI: Factors Affecting Sonographic Detection
Am. J. Roentgenol., May 1, 2010; 194(5): W396 - W400.
[Abstract] [Full Text] [PDF]


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haematolHome page
M. Hussein, J. R. Berenson, R. Niesvizky, N. Munshi, J. Matous, R. Sobecks, K. Harrop, J. G. Drachman, and N. Whiting
A phase I multidose study of dacetuzumab (SGN-40; humanized anti-CD40 monoclonal antibody) in patients with multiple myeloma
Haematologica, May 1, 2010; 95(5): 845 - 848.
[Abstract] [Full Text] [PDF]


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Molecular Cancer TherapeuticsHome page
T. Walker, C. Mitchell, M. A. Park, A. Yacoub, M. Rahmani, D. Haussinger, R. Reinehr, C. Voelkel-Johnson, P. B. Fisher, S. Grant, et al.
17-Allylamino-17-Demethoxygeldanamycin and MEK1/2 Inhibitors Kill GI Tumor Cells via Ca2+-Dependent Suppression of GRP78/BiP and Induction of Ceramide and Reactive Oxygen Species
Mol. Cancer Ther., May 1, 2010; 9(5): 1378 - 1395.
[Abstract] [Full Text] [PDF]


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Ann OncolHome page
T. Kuhnt, A. Sandner, T. Wendt, R. Engenhart-Cabillic, G. Lammering, M. Flentje, G. Grabenbauer, A. Schreiber, A. Pirnasch, and J. Dunst
Phase I trial of dose-escalated cisplatin with concomitant cetuximab and hyperfractionated-accelerated radiotherapy in locally advanced squamous cell carcinoma of the head and neck
Ann. Onc., April 28, 2010; (2010) mdq216v1.
[Abstract] [Full Text] [PDF]


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Clin. Cancer Res.Home page
H. Dopeso, S. Mateo-Lozano, E. Elez, S. Landolfi, F. J. Ramos Pascual, J. Hernandez-Losa, R. Mazzolini, P. Rodrigues, S. Bazzocco, M. J. Carreras, et al.
Aprataxin Tumor Levels Predict Response of Colorectal Cancer Patients to Irinotecan-based Treatment
Clin. Cancer Res., April 15, 2010; 16(8): 2375 - 2382.
[Abstract] [Full Text] [PDF]


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JCOHome page
T. Doi, K. Muro, N. Boku, Y. Yamada, T. Nishina, H. Takiuchi, Y. Komatsu, Y. Hamamoto, N. Ohno, Y. Fujita, et al.
Multicenter Phase II Study of Everolimus in Patients With Previously Treated Metastatic Gastric Cancer
J. Clin. Oncol., April 10, 2010; 28(11): 1904 - 1910.
[Abstract] [Full Text] [PDF]


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CirculationHome page
R. E. Schane, P. M. Ling, and S. A. Glantz
Health Effects of Light and Intermittent Smoking: A Review
Circulation, April 6, 2010; 121(13): 1518 - 1522.
[Full Text] [PDF]


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J Natl Compr Canc NetwHome page
P. Das, Y. Jiang, J. H. Lee, M. S. Bhutani, W. A. Ross, P. F. Mansfield, and J. A. Ajani
Multimodality Approaches to Localized Gastric Cancer
J Natl Compr Canc Netw, April 1, 2010; 8(4): 417 - 425.
[Abstract] [Full Text] [PDF]


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J Natl Compr Canc NetwHome page
M. A. Shah and D. P. Kelsen
Gastric Cancer: A Primer on the Epidemiology and Biology of the Disease and an Overview of the Medical Management of Advanced Disease
J Natl Compr Canc Netw, April 1, 2010; 8(4): 437 - 447.
[Abstract] [Full Text] [PDF]


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Jpn J Clin OncolHome page
P. Zhao, M. Dai, W. Chen, and N. Li
Cancer Trends in China
Jpn. J. Clin. Oncol., April 1, 2010; 40(4): 281 - 285.
[Abstract] [Full Text] [PDF]


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Mol. Endocrinol.Home page
J. A. Aka, M. Mazumdar, C. Q. Chen, D. Poirier, and S. X. Lin
17{beta}-Hydroxysteroid Dehydrogenase Type 1 Stimulates Breast Cancer by Dihydrotestosterone Inactivation in Addition to Estradiol Production
Mol. Endocrinol., April 1, 2010; 24(4): 832 - 845.
[Abstract] [Full Text] [PDF]


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Cancer Epidemiol. Biomarkers Prev.Home page
O. Beiki, F. Granath, P. Allebeck, O. Akre, and T. Moradi
Subtype-Specific Risk of Testicular Tumors among Immigrants and Their Descendants in Sweden, 1960 to 2007
Cancer Epidemiol. Biomarkers Prev., April 1, 2010; 19(4): 1053 - 1065.
[Abstract] [Full Text] [PDF]


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ThoraxHome page
H. Yuan, M.-Y. Li, L. T Ma, M. K Y Hsin, T. S K Mok, M. J Underwood, and G. G Chen
15-Lipoxygenases and its metabolites 15(S)-HETE and 13(S)-HODE in the development of non-small cell lung cancer
Thorax, April 1, 2010; 65(4): 321 - 326.
[Abstract] [Full Text] [PDF]


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Ann OncolHome page
B. Seruga, P. C. Hertz, L. W. Le, and I. F. Tannock
Global drug development in cancer: a cross-sectional study of clinical trial registries
Ann. Onc., April 1, 2010; 21(4): 895 - 900.
[Abstract] [Full Text] [PDF]


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Eur J Public HealthHome page
A. Dee and F. Howell
A cost-utility analysis of adding a bivalent or quadrivalent HPV vaccine to the Irish cervical screening programme
Eur J Public Health, April 1, 2010; 20(2): 213 - 219.
[Abstract] [Full Text] [PDF]


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CarcinogenesisHome page
A. Naccarati, B. Pardini, V. Polakova, Z. Smerhovsky, L. Vodickova, P. Soucek, D. Vrana, I. Holcatova, M. Ryska, and P. Vodicka
Genotype and haplotype analysis of TP53 gene and the risk of pancreatic cancer: an association study in the Czech Republic
Carcinogenesis, April 1, 2010; 31(4): 666 - 670.
[Abstract] [Full Text] [PDF]


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Frontline GastroHome page
L. Rabeneck and L. F Paszat
Circumstances in which colonoscopy misses cancer
Frontline Gastro, April 1, 2010; 1(1): 52 - 58.
[Abstract] [Full Text] [PDF]


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Cancer Res.Home page
J. H. Park, T. Nishidate, K. Kijima, T. Ohashi, K. Takegawa, T. Fujikane, K. Hirata, Y. Nakamura, and T. Katagiri
Critical Roles of Mucin 1 Glycosylation by Transactivated Polypeptide N-Acetylgalactosaminyltransferase 6 in Mammary Carcinogenesis
Cancer Res., April 1, 2010; 70(7): 2759 - 2769.
[Abstract] [Full Text] [PDF]


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Anticancer ResHome page
C.-J. LIU, T.-C. HSIA, R.-F. WANG, C.-W. TSAI, C.-C. CHU, L.-W. HANG, C.-H. WANG, H.-Z. LEE, R.-Y. TSAI, and D.-T. BAU
Interaction of Cyclooxygenase 2 Genotype and Smoking Habit in Taiwanese Lung Cancer Patients
Anticancer Res, April 1, 2010; 30(4): 1195 - 1199.
[Abstract] [Full Text] [PDF]


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Anticancer ResHome page
Y. FUJIWARA, T. NISHIDA, S. TAKIGUCHI, K. NAKAJIMA, H. MIYATA, M. YAMASAKI, K. YAMAMOTO, J.-H. MOON, M. MORI, and Y. DOKI
Feasibility Study of S-1 and Intraperitoneal Docetaxel Combination Chemotherapy for Gastric Cancer with Peritoneal Dissemination
Anticancer Res, April 1, 2010; 30(4): 1335 - 1339.
[Abstract] [Full Text] [PDF]


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Cancer Prevention ResearchHome page
S. E. Weigum, P. N. Floriano, S. W. Redding, C. K. Yeh, S. D. Westbrook, H. S. McGuff, A. Lin, F. R. Miller, F. Villarreal, S. D. Rowan, et al.
Nano-Bio-Chip Sensor Platform for Examination of Oral Exfoliative Cytology
Cancer Prevention Research, April 1, 2010; 3(4): 518 - 528.
[Abstract] [Full Text] [PDF]


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Clin. Cancer Res.Home page
A. Stokes, J. Joutsa, R. Ala-aho, M. Pitchers, C. J. Pennington, C. Martin, D. J. Premachandra, Y. Okada, J. Peltonen, R. Grenman, et al.
Expression Profiles and Clinical Correlations of Degradome Components in the Tumor Microenvironment of Head and Neck Squamous Cell Carcinoma
Clin. Cancer Res., April 1, 2010; 16(7): 2022 - 2035.
[Abstract] [Full Text] [PDF]


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The OncologistHome page
S. Tejpar, M. Bertagnolli, F. Bosman, H. J. Lenz, L. Garraway, F. Waldman, R. Warren, A. Bild, D. Collins-Brennan, H. Hahn, et al.
Prognostic and Predictive Biomarkers in Resected Colon Cancer: Current Status and Future Perspectives for Integrating Genomics into Biomarker Discovery
Oncologist, April 1, 2010; 15(4): 390 - 404.
[Abstract] [Full Text] [PDF]


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Ann OncolHome page
B. F. El-Rayes, M. Zalupski, T. Bekai-Saab, L. K. Heilbrun, N. Hammad, B. Patel, S. Urba, A. F. Shields, U. Vaishampayan, S. Dawson, et al.
A phase II study of bevacizumab, oxaliplatin, and docetaxel in locally advanced and metastatic gastric and gastroesophageal junction cancers
Ann. Onc., March 23, 2010; (2010) mdq065v1.
[Abstract] [Full Text] [PDF]


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JCOHome page
J. A. Ajani, W. Rodriguez, G. Bodoky, V. Moiseyenko, M. Lichinitser, V. Gorbunova, I. Vynnychenko, A. Garin, I. Lang, and S. Falcon
Multicenter Phase III Comparison of Cisplatin/S-1 With Cisplatin/Infusional Fluorouracil in Advanced Gastric or Gastroesophageal Adenocarcinoma Study: The FLAGS Trial
J. Clin. Oncol., March 20, 2010; 28(9): 1547 - 1553.
[Abstract] [Full Text] [PDF]


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JCOHome page
M. Muto, K. Minashi, T. Yano, Y. Saito, I. Oda, S. Nonaka, T. Omori, H. Sugiura, K. Goda, M. Kaise, et al.
Early Detection of Superficial Squamous Cell Carcinoma in the Head and Neck Region and Esophagus by Narrow Band Imaging: A Multicenter Randomized Controlled Trial
J. Clin. Oncol., March 20, 2010; 28(9): 1566 - 1572.
[Abstract] [Full Text] [PDF]


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Cancer Res.Home page
Y. Tsukamoto, C. Nakada, T. Noguchi, M. Tanigawa, L. T. Nguyen, T. Uchida, N. Hijiya, K. Matsuura, T. Fujioka, M. Seto, et al.
MicroRNA-375 Is Downregulated in Gastric Carcinomas and Regulates Cell Survival by Targeting PDK1 and 14-3-3{zeta}
Cancer Res., March 15, 2010; 70(6): 2339 - 2349.
[Abstract] [Full Text] [PDF]


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Clin. Cancer Res.Home page
H. J. Ross, G. R. Blumenschein, Jr., J. Aisner, N. Damjanov, A. Dowlati, J. Garst, J. R. Rigas, M. Smylie, H. Hassani, K. E. Allen, et al.
Randomized Phase II Multicenter Trial of Two Schedules of Lapatinib as First- or Second-Line Monotherapy in Patients with Advanced or Metastatic Non-Small Cell Lung Cancer
Clin. Cancer Res., March 15, 2010; 16(6): 1938 - 1949.
[Abstract] [Full Text] [PDF]




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