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Dr. Parkin is Chief, Unit of Descriptive Epidemiology, International Agency for Research on Cancer, Lyon, France.
Mr. Bray is Epidemiologist, Unit of Descriptive Epidemiology, International Agency for Research on Cancer, Lyon, France.
Mr. Ferlay is Informatics Officer, Unit of Descriptive Epidemiology, International Agency for Research on Cancer, Lyon, France.
Dr. Pisani is Scientist, Unit of Descriptive Epidemiology, International Agency for Research on Cancer, Lyon, France.
Estimates of the worldwide incidence, mortality and prevalence of 26 cancers in the year 2002 are now available in the GLOBOCAN series of the International Agency for Research on Cancer. The results are presented here in summary form, including the geographic variation between 20 large "areas" of the world. Overall, there were 10.9 million new cases, 6.7 million deaths, and 24.6 million persons alive with cancer (within three years of diagnosis). The most commonly diagnosed cancers are lung (1.35 million), breast (1.15 million), and colorectal (1 million); the most common causes of cancer death are lung cancer (1.18 million deaths), stomach cancer (700,000 deaths), and liver cancer (598,000 deaths). The most prevalent cancer in the world is breast cancer (4.4 million survivors up to 5 years following diagnosis). There are striking variations in the risk of different cancers by geographic area. Most of the international variation is due to exposure to known or suspected risk factors related to lifestyle or environment, and provides a clear challenge to prevention.
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T. Walker, C. Mitchell, M. A. Park, A. Yacoub, M. Rahmani, D. Haussinger, R. Reinehr, C. Voelkel-Johnson, P. B. Fisher, S. Grant, et al. 17-Allylamino-17-Demethoxygeldanamycin and MEK1/2 Inhibitors Kill GI Tumor Cells via Ca2+-Dependent Suppression of GRP78/BiP and Induction of Ceramide and Reactive Oxygen Species Mol. Cancer Ther., May 1, 2010; 9(5): 1378 - 1395. [Abstract] [Full Text] [PDF] |
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T. Kuhnt, A. Sandner, T. Wendt, R. Engenhart-Cabillic, G. Lammering, M. Flentje, G. Grabenbauer, A. Schreiber, A. Pirnasch, and J. Dunst Phase I trial of dose-escalated cisplatin with concomitant cetuximab and hyperfractionated-accelerated radiotherapy in locally advanced squamous cell carcinoma of the head and neck Ann. Onc., April 28, 2010; (2010) mdq216v1. [Abstract] [Full Text] [PDF] |
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H. Dopeso, S. Mateo-Lozano, E. Elez, S. Landolfi, F. J. Ramos Pascual, J. Hernandez-Losa, R. Mazzolini, P. Rodrigues, S. Bazzocco, M. J. Carreras, et al. Aprataxin Tumor Levels Predict Response of Colorectal Cancer Patients to Irinotecan-based Treatment Clin. Cancer Res., April 15, 2010; 16(8): 2375 - 2382. [Abstract] [Full Text] [PDF] |
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T. Doi, K. Muro, N. Boku, Y. Yamada, T. Nishina, H. Takiuchi, Y. Komatsu, Y. Hamamoto, N. Ohno, Y. Fujita, et al. Multicenter Phase II Study of Everolimus in Patients With Previously Treated Metastatic Gastric Cancer J. Clin. Oncol., April 10, 2010; 28(11): 1904 - 1910. [Abstract] [Full Text] [PDF] |
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R. E. Schane, P. M. Ling, and S. A. Glantz Health Effects of Light and Intermittent Smoking: A Review Circulation, April 6, 2010; 121(13): 1518 - 1522. [Full Text] [PDF] |
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P. Das, Y. Jiang, J. H. Lee, M. S. Bhutani, W. A. Ross, P. F. Mansfield, and J. A. Ajani Multimodality Approaches to Localized Gastric Cancer J Natl Compr Canc Netw, April 1, 2010; 8(4): 417 - 425. [Abstract] [Full Text] [PDF] |
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M. A. Shah and D. P. Kelsen Gastric Cancer: A Primer on the Epidemiology and Biology of the Disease and an Overview of the Medical Management of Advanced Disease J Natl Compr Canc Netw, April 1, 2010; 8(4): 437 - 447. [Abstract] [Full Text] [PDF] |
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P. Zhao, M. Dai, W. Chen, and N. Li Cancer Trends in China Jpn. J. Clin. Oncol., April 1, 2010; 40(4): 281 - 285. [Abstract] [Full Text] [PDF] |
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J. A. Aka, M. Mazumdar, C. Q. Chen, D. Poirier, and S. X. Lin 17{beta}-Hydroxysteroid Dehydrogenase Type 1 Stimulates Breast Cancer by Dihydrotestosterone Inactivation in Addition to Estradiol Production Mol. Endocrinol., April 1, 2010; 24(4): 832 - 845. [Abstract] [Full Text] [PDF] |
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O. Beiki, F. Granath, P. Allebeck, O. Akre, and T. Moradi Subtype-Specific Risk of Testicular Tumors among Immigrants and Their Descendants in Sweden, 1960 to 2007 Cancer Epidemiol. Biomarkers Prev., April 1, 2010; 19(4): 1053 - 1065. [Abstract] [Full Text] [PDF] |
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H. Yuan, M.-Y. Li, L. T Ma, M. K Y Hsin, T. S K Mok, M. J Underwood, and G. G Chen 15-Lipoxygenases and its metabolites 15(S)-HETE and 13(S)-HODE in the development of non-small cell lung cancer Thorax, April 1, 2010; 65(4): 321 - 326. [Abstract] [Full Text] [PDF] |
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B. Seruga, P. C. Hertz, L. W. Le, and I. F. Tannock Global drug development in cancer: a cross-sectional study of clinical trial registries Ann. Onc., April 1, 2010; 21(4): 895 - 900. [Abstract] [Full Text] [PDF] |
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A. Dee and F. Howell A cost-utility analysis of adding a bivalent or quadrivalent HPV vaccine to the Irish cervical screening programme Eur J Public Health, April 1, 2010; 20(2): 213 - 219. [Abstract] [Full Text] [PDF] |
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A. Naccarati, B. Pardini, V. Polakova, Z. Smerhovsky, L. Vodickova, P. Soucek, D. Vrana, I. Holcatova, M. Ryska, and P. Vodicka Genotype and haplotype analysis of TP53 gene and the risk of pancreatic cancer: an association study in the Czech Republic Carcinogenesis, April 1, 2010; 31(4): 666 - 670. [Abstract] [Full Text] [PDF] |
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L. Rabeneck and L. F Paszat Circumstances in which colonoscopy misses cancer Frontline Gastro, April 1, 2010; 1(1): 52 - 58. [Abstract] [Full Text] [PDF] |
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J. H. Park, T. Nishidate, K. Kijima, T. Ohashi, K. Takegawa, T. Fujikane, K. Hirata, Y. Nakamura, and T. Katagiri Critical Roles of Mucin 1 Glycosylation by Transactivated Polypeptide N-Acetylgalactosaminyltransferase 6 in Mammary Carcinogenesis Cancer Res., April 1, 2010; 70(7): 2759 - 2769. [Abstract] [Full Text] [PDF] |
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C.-J. LIU, T.-C. HSIA, R.-F. WANG, C.-W. TSAI, C.-C. CHU, L.-W. HANG, C.-H. WANG, H.-Z. LEE, R.-Y. TSAI, and D.-T. BAU Interaction of Cyclooxygenase 2 Genotype and Smoking Habit in Taiwanese Lung Cancer Patients Anticancer Res, April 1, 2010; 30(4): 1195 - 1199. [Abstract] [Full Text] [PDF] |
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Y. FUJIWARA, T. NISHIDA, S. TAKIGUCHI, K. NAKAJIMA, H. MIYATA, M. YAMASAKI, K. YAMAMOTO, J.-H. MOON, M. MORI, and Y. DOKI Feasibility Study of S-1 and Intraperitoneal Docetaxel Combination Chemotherapy for Gastric Cancer with Peritoneal Dissemination Anticancer Res, April 1, 2010; 30(4): 1335 - 1339. [Abstract] [Full Text] [PDF] |
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S. E. Weigum, P. N. Floriano, S. W. Redding, C. K. Yeh, S. D. Westbrook, H. S. McGuff, A. Lin, F. R. Miller, F. Villarreal, S. D. Rowan, et al. Nano-Bio-Chip Sensor Platform for Examination of Oral Exfoliative Cytology Cancer Prevention Research, April 1, 2010; 3(4): 518 - 528. [Abstract] [Full Text] [PDF] |
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A. Stokes, J. Joutsa, R. Ala-aho, M. Pitchers, C. J. Pennington, C. Martin, D. J. Premachandra, Y. Okada, J. Peltonen, R. Grenman, et al. Expression Profiles and Clinical Correlations of Degradome Components in the Tumor Microenvironment of Head and Neck Squamous Cell Carcinoma Clin. Cancer Res., April 1, 2010; 16(7): 2022 - 2035. [Abstract] [Full Text] [PDF] |
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S. Tejpar, M. Bertagnolli, F. Bosman, H. J. Lenz, L. Garraway, F. Waldman, R. Warren, A. Bild, D. Collins-Brennan, H. Hahn, et al. Prognostic and Predictive Biomarkers in Resected Colon Cancer: Current Status and Future Perspectives for Integrating Genomics into Biomarker Discovery Oncologist, April 1, 2010; 15(4): 390 - 404. [Abstract] [Full Text] [PDF] |
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B. F. El-Rayes, M. Zalupski, T. Bekai-Saab, L. K. Heilbrun, N. Hammad, B. Patel, S. Urba, A. F. Shields, U. Vaishampayan, S. Dawson, et al. A phase II study of bevacizumab, oxaliplatin, and docetaxel in locally advanced and metastatic gastric and gastroesophageal junction cancers Ann. Onc., March 23, 2010; (2010) mdq065v1. [Abstract] [Full Text] [PDF] |
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J. A. Ajani, W. Rodriguez, G. Bodoky, V. Moiseyenko, M. Lichinitser, V. Gorbunova, I. Vynnychenko, A. Garin, I. Lang, and S. Falcon Multicenter Phase III Comparison of Cisplatin/S-1 With Cisplatin/Infusional Fluorouracil in Advanced Gastric or Gastroesophageal Adenocarcinoma Study: The FLAGS Trial J. Clin. Oncol., March 20, 2010; 28(9): 1547 - 1553. [Abstract] [Full Text] [PDF] |
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M. Muto, K. Minashi, T. Yano, Y. Saito, I. Oda, S. Nonaka, T. Omori, H. Sugiura, K. Goda, M. Kaise, et al. Early Detection of Superficial Squamous Cell Carcinoma in the Head and Neck Region and Esophagus by Narrow Band Imaging: A Multicenter Randomized Controlled Trial J. Clin. Oncol., March 20, 2010; 28(9): 1566 - 1572. [Abstract] [Full Text] [PDF] |
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Y. Tsukamoto, C. Nakada, T. Noguchi, M. Tanigawa, L. T. Nguyen, T. Uchida, N. Hijiya, K. Matsuura, T. Fujioka, M. Seto, et al. MicroRNA-375 Is Downregulated in Gastric Carcinomas and Regulates Cell Survival by Targeting PDK1 and 14-3-3{zeta} Cancer Res., March 15, 2010; 70(6): 2339 - 2349. [Abstract] [Full Text] [PDF] |
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H. J. Ross, G. R. Blumenschein, Jr., J. Aisner, N. Damjanov, A. Dowlati, J. Garst, J. R. Rigas, M. Smylie, H. Hassani, K. E. Allen, et al. Randomized Phase II Multicenter Trial of Two Schedules of Lapatinib as First- or Second-Line Monotherapy in Patients with Advanced or Metastatic Non-Small Cell Lung Cancer Clin. Cancer Res., March 15, 2010; 16(6): 1938 - 1949. [Abstract] [Full Text] [PDF] |
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