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Dr. Jemal is Program Director, Cancer Occurrence, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Ms. Siegel is Manager, Surveillance Information Services, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Dr. Ward is Director, Surveillance Research, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Mr. Murray is Manager, Surveillance Data Systems, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Mr. Xu is Epidemiologist, Mortality Statistics Branch, Division of Vital Statistics, Centers for Disease Control and Prevention, Hyattsville, MD.
Ms. Smigal is Epidemiologist, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Dr. Thun is Vice-President, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Each year, the American Cancer Society estimates the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute and mortality data from the National Center for Health Statistics. Incidence and death rates are age-standardized to the 2000 US standard million population. A total of 1,399,790 new cancer cases and 564,830 deaths from cancer are expected in the United States in 2006. When deaths are aggregated by age, cancer has surpassed heart disease as the leading cause of death for those younger than age 85 since 1999. Delay-adjusted cancer incidence rates stabilized in men from 1995 through 2002, but continued to increase by 0.3% per year from 1987 through 2002 in women. Between 2002 and 2003, the actual number of recorded cancer deaths decreased by 778 in men, but increased by 409 in women, resulting in a net decrease of 369, the first decrease in the total number of cancer deaths since national mortality record keeping was instituted in 1930. The death rate from all cancers combined has decreased by 1.5% per year since 1993 among men and by 0.8% per year since 1992 among women. The mortality rate has also continued to decrease for the three most common cancer sites in men (lung and bronchus, colon and rectum, and prostate) and for breast and colon and rectum cancers in women. Lung cancer mortality among women continues to increase slightly. In analyses by race and ethnicity, African American men and women have 40% and 18% higher death rates from all cancers combined than White men and women, respectively. Cancer incidence and death rates are lower in other racial and ethnic groups than in Whites and African Americans for all sites combined and for the four major cancer sites. However, these groups generally have higher rates for stomach, liver, and cervical cancers than Whites. Furthermore, minority populations are more likely to be diagnosed with advanced stage disease than are Whites. Progress in reducing the burden of suffering and death from cancer can be accelerated by applying existing cancer control knowledge across all segments of the population.
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S. C. Chauhan, K. Vannatta, M. C. Ebeling, N. Vinayek, A. Watanabe, K. K. Pandey, M. C. Bell, M. D. Koch, H. Aburatani, Y. Lio, et al. Expression and Functions of Transmembrane Mucin MUC13 in Ovarian Cancer Cancer Res., February 1, 2009; 69(3): 765 - 774. [Abstract] [Full Text] [PDF] |
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B. Bitik, Y. Kalpakci, E. Altan, E. Dogan, and K. Altundag Successful treatment of primary duodenal carcinoma with bilateral adrenal metastases with docetaxel-cisplatin-5-fluorouracil regimen Ann. Onc., February 1, 2009; 20(2): 394 - 395. [Full Text] [PDF] |
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J.-P. DELORD, C. PUOZZO, F. LEFRESNE, and R. BUGAT Combination Chemotherapy of Vinorelbine and Cisplatin: A Phase I Pharmacokinetic Study in Patients with Metastatic Solid Tumors Anticancer Res, February 1, 2009; 29(2): 553 - 560. [Abstract] [Full Text] [PDF] |
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M. P. Martelli, G. Sozzi, L. Hernandez, V. Pettirossi, A. Navarro, D. Conte, P. Gasparini, F. Perrone, P. Modena, U. Pastorino, et al. EML4-ALK Rearrangement in Non-Small Cell Lung Cancer and Non-Tumor Lung Tissues Am. J. Pathol., February 1, 2009; 174(2): 661 - 670. [Abstract] [Full Text] [PDF] |
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J. D. Murphy, A. C. Spalding, Y. R. Somnay, S. Markwart, M. E. Ray, and D. A. Hamstra Inhibition of mTOR Radiosensitizes Soft Tissue Sarcoma and Tumor Vasculature Clin. Cancer Res., January 15, 2009; 15(2): 589 - 596. [Abstract] [Full Text] [PDF] |
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B. D. Adams, K. P. Claffey, and B. A. White Argonaute-2 Expression Is Regulated by Epidermal Growth Factor Receptor and Mitogen-Activated Protein Kinase Signaling and Correlates with a Transformed Phenotype in Breast Cancer Cells Endocrinology, January 1, 2009; 150(1): 14 - 23. [Abstract] [Full Text] [PDF] |
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N. Nicolaiew, G. Cancel-Tassin, A. R. Azzouzi, B. L. Grand, P. Mangin, L. Cormier, G. Fournier, J.-P. Giordanella, M. Pouchard, J.-L. Escary, et al. Association between estrogen and androgen receptor genes and prostate cancer risk Eur. J. Endocrinol., January 1, 2009; 160(1): 101 - 106. [Abstract] [Full Text] [PDF] |
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J. Lai, S. A. Myers, M. G. Lawrence, D. M. Odorico, and J. A. Clements Direct Progesterone Receptor and Indirect Androgen Receptor Interactions with the Kallikrein-Related Peptidase 4 Gene Promoter in Breast and Prostate Cancer Mol. Cancer Res., January 1, 2009; 7(1): 129 - 141. [Abstract] [Full Text] [PDF] |
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O. Nakajima, A. Matsunaga, D. Ichimaru, Y. Urata, T. Fujiwara, and K. Kawakami Telomerase-specific virotherapy in an animal model of human head and neck cancer Mol. Cancer Ther., January 1, 2009; 8(1): 171 - 177. [Abstract] [Full Text] [PDF] |
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A. AGUZZI, D. MAGGIONI, G. NICOLINI, G. TREDICI, R. M. GAINI, and W. GARAVELLO MAP Kinase Modulation in Squamous Cell Carcinoma of the Oral Cavity Anticancer Res, January 1, 2009; 29(1): 303 - 308. [Abstract] [Full Text] [PDF] |
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P. Roepman, J. Jassem, E. F. Smit, T. Muley, J. Niklinski, T. van de Velde, A. T. Witteveen, W. Rzyman, A. Floore, S. Burgers, et al. An Immune Response Enriched 72-Gene Prognostic Profile for Early-Stage Non-Small-Cell Lung Cancer Clin. Cancer Res., January 1, 2009; 15(1): 284 - 290. [Abstract] [Full Text] [PDF] |
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M.-h. Chang, M. L. Lindegren, M. A. Butler, S. J. Chanock, N. F. Dowling, M. Gallagher, R. Moonesinghe, C. A. Moore, R. M. Ned, M. R. Reichler, et al. Prevalence in the United States of Selected Candidate Gene Variants: Third National Health and Nutrition Examination Survey, 1991-1994 Am. J. Epidemiol., January 1, 2009; 169(1): 54 - 66. [Abstract] [Full Text] [PDF] |
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S. Setoguchi, C. C. Earle, R. Glynn, M. Stedman, J. M. Polinski, C. P. Corcoran, and J. S. Haas Comparison of Prospective and Retrospective Indicators of the Quality of End-of-Life Cancer Care J. Clin. Oncol., December 10, 2008; 26(35): 5671 - 5678. [Abstract] [Full Text] [PDF] |
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M. J. Hassett, M. E. Hughes, J. C. Niland, S. B. Edge, R. L. Theriault, Y.-N. Wong, J. Wilson, W. B. Carter, D. W. Blayney, and J. C. Weeks Chemotherapy Use for Hormone Receptor-Positive, Lymph Node-Negative Breast Cancer J. Clin. Oncol., December 1, 2008; 26(34): 5553 - 5560. [Abstract] [Full Text] [PDF] |
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E. Brignardello, A. Corrias, G. Isolato, N. Palestini, L. Cordero di Montezemolo, F. Fagioli, and G. Boccuzzi Ultrasound Screening for Thyroid Carcinoma in Childhood Cancer Survivors: A Case Series J. Clin. Endocrinol. Metab., December 1, 2008; 93(12): 4840 - 4843. [Abstract] [Full Text] [PDF] |
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N. Mohyuddin, A. Langerman, C. LeHew, L. Kaste, and K. Pytynia Knowledge of Head and Neck Cancer Among Medical Students at 2 Chicago Universities Arch Otolaryngol Head Neck Surg, December 1, 2008; 134(12): 1294 - 1298. [Abstract] [Full Text] [PDF] |
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S. Kim-Schulze, H. S. Kim, A. Wainstein, D. W. Kim, W. C. Yang, D. Moroziewicz, P. Y. Mong, M. Bereta, B. Taback, Q. Wang, et al. Intrarectal Vaccination with Recombinant Vaccinia Virus Expressing Carcinoembronic Antigen Induces Mucosal and Systemic Immunity and Prevents Progression of Colorectal Cancer J. Immunol., December 1, 2008; 181(11): 8112 - 8119. [Abstract] [Full Text] [PDF] |
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P. Ordonez-Moran, M. J. Larriba, H. G. Palmer, R. A. Valero, A. Barbachano, M. Dunach, A. G. de Herreros, C. Villalobos, M. T. Berciano, M. Lafarga, et al. RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells J. Cell Biol., November 17, 2008; 183(4): 697 - 710. [Abstract] [Full Text] [PDF] |
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O. Rayhman, E. Klipper, L. Muller, B. Davidson, R. Reich, and R. Meidan Small Interfering RNA Molecules Targeting Endothelin-Converting Enzyme-1 Inhibit Endothelin-1 Synthesis and the Invasive Phenotype of Ovarian Carcinoma Cells Cancer Res., November 15, 2008; 68(22): 9265 - 9273. [Abstract] [Full Text] [PDF] |
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T. Tanaka, M. Ikeda, T. Okusaka, H. Ueno, C. Morizane, A. Hagihara, S. Iwasa, and Y. Kojima Prognostic Factors in Japanese Patients with Advanced Pancreatic Cancer Treated with Single-agent Gemcitabine as First-line Therapy Jpn. J. Clin. Oncol., November 1, 2008; 38(11): 755 - 761. [Abstract] [Full Text] [PDF] |
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E. Tassi, F. Gavazzi, L. Albarello, V. Senyukov, R. Longhi, P. Dellabona, C. Doglioni, M. Braga, V. Di Carlo, and M. P. Protti Carcinoembryonic Antigen-Specific but Not Antiviral CD4+ T Cell Immunity Is Impaired in Pancreatic Carcinoma Patients J. Immunol., November 1, 2008; 181(9): 6595 - 6603. [Abstract] [Full Text] [PDF] |
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J. J. Liang, H. Wang, A. Rashid, T.-H. Tan, R. F. Hwang, S. R. Hamilton, J. L. Abbruzzese, D. B. Evans, and H. Wang Expression of MAP4K4 Is Associated with Worse Prognosis in Patients with Stage II Pancreatic Ductal Adenocarcinoma Clin. Cancer Res., November 1, 2008; 14(21): 7043 - 7049. [Abstract] [Full Text] [PDF] |
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D. Xiao, A. A. Powolny, and S. V. Singh Benzyl Isothiocyanate Targets Mitochondrial Respiratory Chain to Trigger Reactive Oxygen Species-dependent Apoptosis in Human Breast Cancer Cells J. Biol. Chem., October 31, 2008; 283(44): 30151 - 30163. [Abstract] [Full Text] [PDF] |
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