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CA Cancer J Clin 2007; 57:43-66
doi: 10.3322/canjclin.57.1.43
© 2007 American Cancer Society
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Cancer Statistics, 2007

Ahmedin Jemal, DVM,PhD, Rebecca Siegel, MPH, Elizabeth Ward, PhD, Taylor Murray, Jiaquan Xu and Michael J. Thun, MD,MS

Dr. Jemal is Strategic Director, Cancer Occurrence, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Ms. Siegel is Manager, Surveillance Information Services, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Dr. Ward is Managing Director, Surveillance Research, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Mr. Murray is Manager, Surveillance Data Systems, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Mr. Xu is Analyst, Mortality Statistics Branch, Division of Vital Statistics, Centers for Disease Control and Prevention, Hyattsville, MD.
Dr. Thun is Vice President, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.

This article is available online at http://CAonline.AmCancerSoc.org

Each year, the American Cancer Society (ACS) estimates the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute, Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries and mortality data from the National Center for Health Statistics. This report considers incidence data through 2003 and mortality data through 2004. Incidence and death rates are age-standardized to the 2000 US standard million population. A total of 1,444,920 new cancer cases and 559,650 deaths for cancers are projected to occur in the United States in 2007. Notable trends in cancer incidence and mortality rates include stabilization of the age-standardized, delay-adjusted incidence rates for all cancers combined in men from 1995 through 2003; a continuing increase in the incidence rate by 0.3% per year in women; and a 13.6% total decrease in age-standardized cancer death rates among men and women combined between 1991 and 2004. This report also examines cancer incidence, mortality, and survival by site, sex, race/ethnicity, geographic area, and calendar year, as well as the proportionate contribution of selected sites to the overall trends. While the absolute number of cancer deaths decreased for the second consecutive year in the United States (by more than 3,000 from 2003 to 2004) and much progress has been made in reducing mortality rates and improving survival, cancer still accounts for more deaths than heart disease in persons under age 85 years. Further progress can be accelerated by supporting new discoveries and by applying existing cancer control knowledge across all segments of the population.




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X.-R. Yang, Y. Xu, B. Yu, J. Zhou, J.-C. Li, S.-J. Qiu, Y.-H. Shi, X.-Y. Wang, Z. Dai, G.-M. Shi, et al.
CD24 Is a Novel Predictor for Poor Prognosis of Hepatocellular Carcinoma after Surgery
Clin. Cancer Res., September 1, 2009; 15(17): 5518 - 5527.
[Abstract] [Full Text] [PDF]


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Clin. Cancer Res.Home page
G. Komar, S. Kauhanen, K. Liukko, M. Seppanen, S. Kajander, J. Ovaska, P. Nuutila, and H. Minn
Decreased Blood Flow with Increased Metabolic Activity: A Novel Sign of Pancreatic Tumor Aggressiveness
Clin. Cancer Res., September 1, 2009; 15(17): 5511 - 5517.
[Abstract] [Full Text] [PDF]


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Ann OncolHome page
K. J. Ruddy, S. Gelber, J. Shin, J. E. Garber, R. Rosenberg, M. Przypysny, and A. H. Partridge
Genetic testing in young women with breast cancer: results from a Web-based survey
Ann. Onc., August 27, 2009; (2009) mdp355v1.
[Abstract] [Full Text] [PDF]


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Cancer Res.Home page
A. Takano, N. Ishikawa, R. Nishino, K. Masuda, W. Yasui, K. Inai, H. Nishimura, H. Ito, H. Nakayama, Y. Miyagi, et al.
Identification of Nectin-4 Oncoprotein as a Diagnostic and Therapeutic Target for Lung Cancer
Cancer Res., August 15, 2009; 69(16): 6694 - 6703.
[Abstract] [Full Text] [PDF]


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Clin. Cancer Res.Home page
Z. Zhang, Y. Huang, K. Newman, J. Gu, X. Zhang, H. Wu, M. Zhao, Z. Xianyu, and X. Liu
Reexpression of Human Somatostatin Receptor Gene 2 Gene Mediated by Oncolytic Adenovirus Increases Antitumor Activity of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand against Pancreatic Cancer
Clin. Cancer Res., August 15, 2009; 15(16): 5154 - 5160.
[Abstract] [Full Text] [PDF]


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Clin. Cancer Res.Home page
J.-Y. Choi, W. E. Barlow, K. S. Albain, C.-C. Hong, J. G. Blanco, R. B. Livingston, W. Davis, J. M. Rae, I-T. Yeh, L. F. Hutchins, et al.
Nitric Oxide Synthase Variants and Disease-Free Survival among Treated and Untreated Breast Cancer Patients in a Southwest Oncology Group Clinical Trial
Clin. Cancer Res., August 15, 2009; 15(16): 5258 - 5266.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
S. A. Maxwell, Z. Li, D. Jaya, S. Ballard, J. Ferrell, and H. Fu
14-3-3{zeta} Mediates Resistance of Diffuse Large B Cell Lymphoma to an Anthracycline-based Chemotherapeutic Regimen
J. Biol. Chem., August 14, 2009; 284(33): 22379 - 22389.
[Abstract] [Full Text] [PDF]


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Cancer Epidemiol. Biomarkers Prev.Home page
E. Kolwijck, P. L.M. Zusterzeel, H. M.J. Roelofs, J. C. Hendriks, W. H.M. Peters, and L. F.A.G. Massuger
GSTP1-1 in Ovarian Cyst Fluid and Disease Outcome of Patients With Ovarian Cancer
Cancer Epidemiol. Biomarkers Prev., August 1, 2009; 18(8): 2176 - 2181.
[Abstract] [Full Text] [PDF]


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Therapeutic Advances in UrologyHome page
K. F. Sullivan and E. D. Crawford
Targeted focal therapy for prostate cancer: a review of the literature
Therapeutic Advances in Urology, August 1, 2009; 1(3): 149 - 159.
[Abstract] [PDF]


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CarcinogenesisHome page
M. Li, H. Edamatsu, R. Kitazawa, S. Kitazawa, and T. Kataoka
Phospholipase C{varepsilon} promotes intestinal tumorigenesis of ApcMin/+ mice through augmentation of inflammation and angiogenesis
Carcinogenesis, August 1, 2009; 30(8): 1424 - 1432.
[Abstract] [Full Text] [PDF]


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CarcinogenesisHome page
J. Zabaleta, L. J. Su, H.-Y. Lin, R. A. Sierra, M. C. Hall, A. O. Sartor, P. E. Clark, J. J. Hu, and A. C. Ochoa
Cytokine genetic polymorphisms and prostate cancer aggressiveness
Carcinogenesis, August 1, 2009; 30(8): 1358 - 1362.
[Abstract] [Full Text] [PDF]


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Anticancer ResHome page
M. CHIRUMBOLE, N. GUSANI, A. HOWARD, T. LEONARD, P. LEWIS, and J. MUSCAT
A Comparison of Stage of Presentation for Pancreatic and Colorectal Cancer in Pennsylvania 2000-2005
Anticancer Res, August 1, 2009; 29(8): 3427 - 3431.
[Abstract] [Full Text] [PDF]


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Int J EpidemiolHome page
M. Hosseini, P. A. Naghan, S. Karimi, S. SeyedAlinaghi, M. Bahadori, K. Khodadad, F. Mohammadi, K. Keynama, and M. R. Masjedi
Environmental risk factors for lung cancer in Iran: a case-control study
Int. J. Epidemiol., August 1, 2009; 38(4): 989 - 996.
[Abstract] [Full Text] [PDF]


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Cancer Res.Home page
E. Yang, A. Boire, A. Agarwal, N. Nguyen, K. O'Callaghan, P. Tu, A. Kuliopulos, and L. Covic
Blockade of PAR1 Signaling with Cell-Penetrating Pepducins Inhibits Akt Survival Pathways in Breast Cancer Cells and Suppresses Tumor Survival and Metastasis
Cancer Res., August 1, 2009; 69(15): 6223 - 6231.
[Abstract] [Full Text] [PDF]


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J. Med. Genet.Home page
S Ghavami, M Hashemi, S R Ande, B Yeganeh, W Xiao, M Eshraghi, C J Bus, K Kadkhoda, E Wiechec, A J Halayko, et al.
Apoptosis and cancer: mutations within caspase genes
J. Med. Genet., August 1, 2009; 46(8): 497 - 510.
[Abstract] [Full Text] [PDF]


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Molecular Cancer TherapeuticsHome page
C. Li, Y. Zang, M. Sen, R. J. Leeman-Neill, D. SK. Man, J. R. Grandis, and D. E. Johnson
Bortezomib up-regulates activated signal transducer and activator of transcription-3 and synergizes with inhibitors of signal transducer and activator of transcription-3 to promote head and neck squamous cell carcinoma cell death
Mol. Cancer Ther., August 1, 2009; 8(8): 2211 - 2220.
[Abstract] [Full Text] [PDF]


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Clin. Cancer Res.Home page
K. E. Knudsen and H. I. Scher
Starving the Addiction: New Opportunities for Durable Suppression of AR Signaling in Prostate Cancer
Clin. Cancer Res., August 1, 2009; 15(15): 4792 - 4798.
[Abstract] [Full Text] [PDF]


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Cancer Res.Home page
Y. Xie, D. W. Wolff, T. Wei, B. Wang, C. Deng, J. K. Kirui, H. Jiang, J. Qin, P. W. Abel, and Y. Tu
Breast Cancer Migration and Invasion Depend on Proteasome Degradation of Regulator of G-Protein Signaling 4
Cancer Res., July 15, 2009; 69(14): 5743 - 5751.
[Abstract] [Full Text] [PDF]


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Cancer Res.Home page
L. Bao, M. A. Gorin, M. Zhang, A. C. Ventura, W. C. Pomerantz, S. D. Merajver, T. N. Teknos, A. K. Mapp, and Q. Pan
Preclinical Development of a Bifunctional Cancer Cell Homing, PKC{varepsilon} Inhibitory Peptide for the Treatment of Head and Neck Cancer
Cancer Res., July 15, 2009; 69(14): 5829 - 5834.
[Abstract] [Full Text] [PDF]


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Cancer Res.Home page
M. Raponi, L. Dossey, T. Jatkoe, X. Wu, G. Chen, H. Fan, and D. G. Beer
MicroRNA Classifiers for Predicting Prognosis of Squamous Cell Lung Cancer
Cancer Res., July 15, 2009; 69(14): 5776 - 5783.
[Abstract] [Full Text] [PDF]


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JCOHome page
B. Escudier, T. Eisen, W. M. Stadler, C. Szczylik, S. Oudard, M. Staehler, S. Negrier, C. Chevreau, A. A. Desai, F. Rolland, et al.
Sorafenib for Treatment of Renal Cell Carcinoma: Final Efficacy and Safety Results of the Phase III Treatment Approaches in Renal Cancer Global Evaluation Trial
J. Clin. Oncol., July 10, 2009; 27(20): 3312 - 3318.
[Abstract] [Full Text] [PDF]


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Therapeutic Advances in Medical OncologyHome page
J. M.G. Larkin, E. L.S. Kipps, C. J. Powell, and C. Swanton
Review: Systemic therapy for advanced renal cell carcinoma
Therapeutic Advances in Medical Oncology, July 1, 2009; 1(1): 15 - 27.
[Abstract] [PDF]


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The Obstetrician and GynaecologistHome page
A. Mariani, S. C Dowdy, and K. C Podratz
The role of pelvic and para-aortic lymph node dissection in the surgical treatment of endometrial cancer: a view from the USA
Obstet Gynaecol (Lond), July 1, 2009; 11(3): 199 - 204.
[Abstract] [Full Text] [PDF]


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Cancer Epidemiol. Biomarkers Prev.Home page
J. Lin, A. Kamat, J. Gu, M. Chen, C. P. Dinney, M. R. Forman, and X. Wu
Dietary Intake of Vegetables and Fruits and the Modification Effects of GSTM1 and NAT2 Genotypes on Bladder Cancer Risk
Cancer Epidemiol. Biomarkers Prev., July 1, 2009; 18(7): 2090 - 2097.
[Abstract] [Full Text] [PDF]


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Ann OncolHome page
C. H. Barrios, C. Sampaio, J. Vinholes, and R. Caponero
What is the role of chemotherapy in estrogen receptor-positive, advanced breast cancer?
Ann. Onc., July 1, 2009; 20(7): 1157 - 1162.
[Abstract] [Full Text] [PDF]


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Ann OncolHome page
S. J. Cohen, C. J. A. Punt, N. Iannotti, B. H. Saidman, K. D. Sabbath, N. Y. Gabrail, J. Picus, M. A. Morse, E. Mitchell, M. C. Miller, et al.
Prognostic significance of circulating tumor cells in patients with metastatic colorectal cancer
Ann. Onc., July 1, 2009; 20(7): 1223 - 1229.
[Abstract] [Full Text] [PDF]


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CarcinogenesisHome page
R. A. Mason, E. V. Morlock, M. R. Karagas, K. T. Kelsey, C. J. Marsit, A. R. Schned, and A. S. Andrew
EGFR pathway polymorphisms and bladder cancer susceptibility and prognosis
Carcinogenesis, July 1, 2009; 30(7): 1155 - 1160.
[Abstract] [Full Text] [PDF]


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CA Cancer J ClinHome page
P. Boyle and O. W. Brawley
Prostate Cancer: Current Evidence Weighs Against Population Screening
CA Cancer J Clin, July 1, 2009; 59(4): 220 - 224.
[Full Text] [PDF]


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Cancer Res.Home page
N. Bandi, S. Zbinden, M. Gugger, M. Arnold, V. Kocher, L. Hasan, A. Kappeler, T. Brunner, and E. Vassella
miR-15a and miR-16 Are Implicated in Cell Cycle Regulation in a Rb-Dependent Manner and Are Frequently Deleted or Down-regulated in Non-Small Cell Lung Cancer
Cancer Res., July 1, 2009; 69(13): 5553 - 5559.
[Abstract] [Full Text] [PDF]


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Molecular Cancer TherapeuticsHome page
S.-H. Kim and S. V. Singh
D,L-Sulforaphane causes transcriptional repression of androgen receptor in human prostate cancer cells
Mol. Cancer Ther., July 1, 2009; 8(7): 1946 - 1954.
[Abstract] [Full Text] [PDF]


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Molecular Cancer TherapeuticsHome page
M. K. McElroy, S. Kaushal, H. S. Tran Cao, A.R. Moossa, M. A. Talamini, R. M. Hoffman, and M. Bouvet
Upregulation of thrombospondin-1 and angiogenesis in an aggressive human pancreatic cancer cell line selected for high metastasis
Mol. Cancer Ther., July 1, 2009; 8(7): 1779 - 1786.
[Abstract] [Full Text] [PDF]


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Clin. Cancer Res.Home page
A. L. Russo, K. Jedlicka, M. Wernick, D. McNally, M. Kirk, M. Sproull, S. Smith, U. Shankavaram, A. Kaushal, W. D. Figg, et al.
Urine Analysis and Protein Networking Identify Met as a Marker of Metastatic Prostate Cancer
Clin. Cancer Res., July 1, 2009; 15(13): 4292 - 4298.
[Abstract] [Full Text] [PDF]


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JCOHome page
L. T. Vahdat, B. Pruitt, C. J. Fabian, R. R. Rivera, D. A. Smith, E. Tan-Chiu, J. Wright, A. R. Tan, N. A. DaCosta, E. Chuang, et al.
Phase II Study of Eribulin Mesylate, a Halichondrin B Analog, in Patients With Metastatic Breast Cancer Previously Treated With an Anthracycline and a Taxane
J. Clin. Oncol., June 20, 2009; 27(18): 2954 - 2961.
[Abstract] [Full Text] [PDF]


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JCOHome page
F. D. Ferris, E. Bruera, N. Cherny, C. Cummings, D. Currow, D. Dudgeon, N. JanJan, F. Strasser, C. F. von Gunten, and J. H. Von Roenn
Palliative Cancer Care a Decade Later: Accomplishments, the Need, Next Steps--From the American Society of Clinical Oncology
J. Clin. Oncol., June 20, 2009; 27(18): 3052 - 3058.
[Abstract] [Full Text] [PDF]


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Clin. Cancer Res.Home page
J. Li, H. Huang, L. Sun, M. Yang, C. Pan, W. Chen, D. Wu, Z. Lin, C. Zeng, Y. Yao, et al.
MiR-21 Indicates Poor Prognosis in Tongue Squamous Cell Carcinomas as an Apoptosis Inhibitor
Clin. Cancer Res., June 15, 2009; 15(12): 3998 - 4008.
[Abstract] [Full Text] [PDF]


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JCOHome page
J. Yee, M. D. Sadar, D. D. Sin, M. Kuzyk, L. Xing, J. Kondra, A. McWilliams, S.F. P. Man, and S. Lam
Connective Tissue-Activating Peptide III: A Novel Blood Biomarker for Early Lung Cancer Detection
J. Clin. Oncol., June 10, 2009; 27(17): 2787 - 2792.
[Abstract] [Full Text] [PDF]


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JCOHome page
S. Tomida, T. Takeuchi, Y. Shimada, C. Arima, K. Matsuo, T. Mitsudomi, Y. Yatabe, and T. Takahashi
Relapse-Related Molecular Signature in Lung Adenocarcinomas Identifies Patients With Dismal Prognosis
J. Clin. Oncol., June 10, 2009; 27(17): 2793 - 2799.
[Abstract] [Full Text] [PDF]




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