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Dr. Jemal is Strategic Director, Cancer Occurrence, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Ms. Siegel is Manager, Surveillance Information Services, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Dr. Ward is Managing Director, Surveillance Research, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Mr. Murray is Manager, Surveillance Data Systems, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Mr. Xu is Analyst, Mortality Statistics Branch, Division of Vital Statistics, Centers for Disease Control and Prevention, Hyattsville, MD.
Dr. Thun is Vice President, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
This article is available online at http://CAonline.AmCancerSoc.org
Each year, the American Cancer Society (ACS) estimates the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute, Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries and mortality data from the National Center for Health Statistics. This report considers incidence data through 2003 and mortality data through 2004. Incidence and death rates are age-standardized to the 2000 US standard million population. A total of 1,444,920 new cancer cases and 559,650 deaths for cancers are projected to occur in the United States in 2007. Notable trends in cancer incidence and mortality rates include stabilization of the age-standardized, delay-adjusted incidence rates for all cancers combined in men from 1995 through 2003; a continuing increase in the incidence rate by 0.3% per year in women; and a 13.6% total decrease in age-standardized cancer death rates among men and women combined between 1991 and 2004. This report also examines cancer incidence, mortality, and survival by site, sex, race/ethnicity, geographic area, and calendar year, as well as the proportionate contribution of selected sites to the overall trends. While the absolute number of cancer deaths decreased for the second consecutive year in the United States (by more than 3,000 from 2003 to 2004) and much progress has been made in reducing mortality rates and improving survival, cancer still accounts for more deaths than heart disease in persons under age 85 years. Further progress can be accelerated by supporting new discoveries and by applying existing cancer control knowledge across all segments of the population.
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M. Li, H. Edamatsu, R. Kitazawa, S. Kitazawa, and T. Kataoka Phospholipase C{varepsilon} promotes intestinal tumorigenesis of ApcMin/+ mice through augmentation of inflammation and angiogenesis Carcinogenesis, August 1, 2009; 30(8): 1424 - 1432. [Abstract] [Full Text] [PDF] |
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J. Zabaleta, L. J. Su, H.-Y. Lin, R. A. Sierra, M. C. Hall, A. O. Sartor, P. E. Clark, J. J. Hu, and A. C. Ochoa Cytokine genetic polymorphisms and prostate cancer aggressiveness Carcinogenesis, August 1, 2009; 30(8): 1358 - 1362. [Abstract] [Full Text] [PDF] |
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M. CHIRUMBOLE, N. GUSANI, A. HOWARD, T. LEONARD, P. LEWIS, and J. MUSCAT A Comparison of Stage of Presentation for Pancreatic and Colorectal Cancer in Pennsylvania 2000-2005 Anticancer Res, August 1, 2009; 29(8): 3427 - 3431. [Abstract] [Full Text] [PDF] |
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M. Hosseini, P. A. Naghan, S. Karimi, S. SeyedAlinaghi, M. Bahadori, K. Khodadad, F. Mohammadi, K. Keynama, and M. R. Masjedi Environmental risk factors for lung cancer in Iran: a case-control study Int. J. Epidemiol., August 1, 2009; 38(4): 989 - 996. [Abstract] [Full Text] [PDF] |
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E. Yang, A. Boire, A. Agarwal, N. Nguyen, K. O'Callaghan, P. Tu, A. Kuliopulos, and L. Covic Blockade of PAR1 Signaling with Cell-Penetrating Pepducins Inhibits Akt Survival Pathways in Breast Cancer Cells and Suppresses Tumor Survival and Metastasis Cancer Res., August 1, 2009; 69(15): 6223 - 6231. [Abstract] [Full Text] [PDF] |
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S Ghavami, M Hashemi, S R Ande, B Yeganeh, W Xiao, M Eshraghi, C J Bus, K Kadkhoda, E Wiechec, A J Halayko, et al. Apoptosis and cancer: mutations within caspase genes J. Med. Genet., August 1, 2009; 46(8): 497 - 510. [Abstract] [Full Text] [PDF] |
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C. Li, Y. Zang, M. Sen, R. J. Leeman-Neill, D. SK. Man, J. R. Grandis, and D. E. Johnson Bortezomib up-regulates activated signal transducer and activator of transcription-3 and synergizes with inhibitors of signal transducer and activator of transcription-3 to promote head and neck squamous cell carcinoma cell death Mol. Cancer Ther., August 1, 2009; 8(8): 2211 - 2220. [Abstract] [Full Text] [PDF] |
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K. E. Knudsen and H. I. Scher Starving the Addiction: New Opportunities for Durable Suppression of AR Signaling in Prostate Cancer Clin. Cancer Res., August 1, 2009; 15(15): 4792 - 4798. [Abstract] [Full Text] [PDF] |
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Y. Xie, D. W. Wolff, T. Wei, B. Wang, C. Deng, J. K. Kirui, H. Jiang, J. Qin, P. W. Abel, and Y. Tu Breast Cancer Migration and Invasion Depend on Proteasome Degradation of Regulator of G-Protein Signaling 4 Cancer Res., July 15, 2009; 69(14): 5743 - 5751. [Abstract] [Full Text] [PDF] |
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L. Bao, M. A. Gorin, M. Zhang, A. C. Ventura, W. C. Pomerantz, S. D. Merajver, T. N. Teknos, A. K. Mapp, and Q. Pan Preclinical Development of a Bifunctional Cancer Cell Homing, PKC{varepsilon} Inhibitory Peptide for the Treatment of Head and Neck Cancer Cancer Res., July 15, 2009; 69(14): 5829 - 5834. [Abstract] [Full Text] [PDF] |
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M. Raponi, L. Dossey, T. Jatkoe, X. Wu, G. Chen, H. Fan, and D. G. Beer MicroRNA Classifiers for Predicting Prognosis of Squamous Cell Lung Cancer Cancer Res., July 15, 2009; 69(14): 5776 - 5783. [Abstract] [Full Text] [PDF] |
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B. Escudier, T. Eisen, W. M. Stadler, C. Szczylik, S. Oudard, M. Staehler, S. Negrier, C. Chevreau, A. A. Desai, F. Rolland, et al. Sorafenib for Treatment of Renal Cell Carcinoma: Final Efficacy and Safety Results of the Phase III Treatment Approaches in Renal Cancer Global Evaluation Trial J. Clin. Oncol., July 10, 2009; 27(20): 3312 - 3318. [Abstract] [Full Text] [PDF] |
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J. M.G. Larkin, E. L.S. Kipps, C. J. Powell, and C. Swanton Review: Systemic therapy for advanced renal cell carcinoma Therapeutic Advances in Medical Oncology, July 1, 2009; 1(1): 15 - 27. [Abstract] [PDF] |
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A. Mariani, S. C Dowdy, and K. C Podratz The role of pelvic and para-aortic lymph node dissection in the surgical treatment of endometrial cancer: a view from the USA Obstet Gynaecol (Lond), July 1, 2009; 11(3): 199 - 204. [Abstract] [Full Text] [PDF] |
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J. Lin, A. Kamat, J. Gu, M. Chen, C. P. Dinney, M. R. Forman, and X. Wu Dietary Intake of Vegetables and Fruits and the Modification Effects of GSTM1 and NAT2 Genotypes on Bladder Cancer Risk Cancer Epidemiol. Biomarkers Prev., July 1, 2009; 18(7): 2090 - 2097. [Abstract] [Full Text] [PDF] |
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C. H. Barrios, C. Sampaio, J. Vinholes, and R. Caponero What is the role of chemotherapy in estrogen receptor-positive, advanced breast cancer? Ann. Onc., July 1, 2009; 20(7): 1157 - 1162. [Abstract] [Full Text] [PDF] |
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S. J. Cohen, C. J. A. Punt, N. Iannotti, B. H. Saidman, K. D. Sabbath, N. Y. Gabrail, J. Picus, M. A. Morse, E. Mitchell, M. C. Miller, et al. Prognostic significance of circulating tumor cells in patients with metastatic colorectal cancer Ann. Onc., July 1, 2009; 20(7): 1223 - 1229. [Abstract] [Full Text] [PDF] |
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R. A. Mason, E. V. Morlock, M. R. Karagas, K. T. Kelsey, C. J. Marsit, A. R. Schned, and A. S. Andrew EGFR pathway polymorphisms and bladder cancer susceptibility and prognosis Carcinogenesis, July 1, 2009; 30(7): 1155 - 1160. [Abstract] [Full Text] [PDF] |
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P. Boyle and O. W. Brawley Prostate Cancer: Current Evidence Weighs Against Population Screening CA Cancer J Clin, July 1, 2009; 59(4): 220 - 224. [Full Text] [PDF] |
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N. Bandi, S. Zbinden, M. Gugger, M. Arnold, V. Kocher, L. Hasan, A. Kappeler, T. Brunner, and E. Vassella miR-15a and miR-16 Are Implicated in Cell Cycle Regulation in a Rb-Dependent Manner and Are Frequently Deleted or Down-regulated in Non-Small Cell Lung Cancer Cancer Res., July 1, 2009; 69(13): 5553 - 5559. [Abstract] [Full Text] [PDF] |
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S.-H. Kim and S. V. Singh D,L-Sulforaphane causes transcriptional repression of androgen receptor in human prostate cancer cells Mol. Cancer Ther., July 1, 2009; 8(7): 1946 - 1954. [Abstract] [Full Text] [PDF] |
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M. K. McElroy, S. Kaushal, H. S. Tran Cao, A.R. Moossa, M. A. Talamini, R. M. Hoffman, and M. Bouvet Upregulation of thrombospondin-1 and angiogenesis in an aggressive human pancreatic cancer cell line selected for high metastasis Mol. Cancer Ther., July 1, 2009; 8(7): 1779 - 1786. [Abstract] [Full Text] [PDF] |
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A. L. Russo, K. Jedlicka, M. Wernick, D. McNally, M. Kirk, M. Sproull, S. Smith, U. Shankavaram, A. Kaushal, W. D. Figg, et al. Urine Analysis and Protein Networking Identify Met as a Marker of Metastatic Prostate Cancer Clin. Cancer Res., July 1, 2009; 15(13): 4292 - 4298. [Abstract] [Full Text] [PDF] |
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L. T. Vahdat, B. Pruitt, C. J. Fabian, R. R. Rivera, D. A. Smith, E. Tan-Chiu, J. Wright, A. R. Tan, N. A. DaCosta, E. Chuang, et al. Phase II Study of Eribulin Mesylate, a Halichondrin B Analog, in Patients With Metastatic Breast Cancer Previously Treated With an Anthracycline and a Taxane J. Clin. Oncol., June 20, 2009; 27(18): 2954 - 2961. [Abstract] [Full Text] [PDF] |
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F. D. Ferris, E. Bruera, N. Cherny, C. Cummings, D. Currow, D. Dudgeon, N. JanJan, F. Strasser, C. F. von Gunten, and J. H. Von Roenn Palliative Cancer Care a Decade Later: Accomplishments, the Need, Next Steps--From the American Society of Clinical Oncology J. Clin. Oncol., June 20, 2009; 27(18): 3052 - 3058. [Abstract] [Full Text] [PDF] |
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J. Li, H. Huang, L. Sun, M. Yang, C. Pan, W. Chen, D. Wu, Z. Lin, C. Zeng, Y. Yao, et al. MiR-21 Indicates Poor Prognosis in Tongue Squamous Cell Carcinomas as an Apoptosis Inhibitor Clin. Cancer Res., June 15, 2009; 15(12): 3998 - 4008. [Abstract] [Full Text] [PDF] |
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J. Yee, M. D. Sadar, D. D. Sin, M. Kuzyk, L. Xing, J. Kondra, A. McWilliams, S.F. P. Man, and S. Lam Connective Tissue-Activating Peptide III: A Novel Blood Biomarker for Early Lung Cancer Detection J. Clin. Oncol., June 10, 2009; 27(17): 2787 - 2792. [Abstract] [Full Text] [PDF] |
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S. Tomida, T. Takeuchi, Y. Shimada, C. Arima, K. Matsuo, T. Mitsudomi, Y. Yatabe, and T. Takahashi Relapse-Related Molecular Signature in Lung Adenocarcinomas Identifies Patients With Dismal Prognosis J. Clin. Oncol., June 10, 2009; 27(17): 2793 - 2799. [Abstract] [Full Text] [PDF] |
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