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Dr. Jemal is Strategic Director, Cancer Occurrence, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Ms. Siegel is Manager, Surveillance Information Services, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Dr. Ward is Managing Director, Surveillance Research, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Mr. Murray is Manager, Surveillance Data Systems, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Mr. Xu is Analyst, Mortality Statistics Branch, Division of Vital Statistics, Centers for Disease Control and Prevention, Hyattsville, MD.
Dr. Thun is Vice President, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
This article is available online at http://CAonline.AmCancerSoc.org
Each year, the American Cancer Society (ACS) estimates the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute, Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries and mortality data from the National Center for Health Statistics. This report considers incidence data through 2003 and mortality data through 2004. Incidence and death rates are age-standardized to the 2000 US standard million population. A total of 1,444,920 new cancer cases and 559,650 deaths for cancers are projected to occur in the United States in 2007. Notable trends in cancer incidence and mortality rates include stabilization of the age-standardized, delay-adjusted incidence rates for all cancers combined in men from 1995 through 2003; a continuing increase in the incidence rate by 0.3% per year in women; and a 13.6% total decrease in age-standardized cancer death rates among men and women combined between 1991 and 2004. This report also examines cancer incidence, mortality, and survival by site, sex, race/ethnicity, geographic area, and calendar year, as well as the proportionate contribution of selected sites to the overall trends. While the absolute number of cancer deaths decreased for the second consecutive year in the United States (by more than 3,000 from 2003 to 2004) and much progress has been made in reducing mortality rates and improving survival, cancer still accounts for more deaths than heart disease in persons under age 85 years. Further progress can be accelerated by supporting new discoveries and by applying existing cancer control knowledge across all segments of the population.
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 F. Farjah, D. R. Flum, T. K. Varghese Jr, R. G. Symons, and D. E. Wood Surgeon Specialty and Long-Term Survival After Pulmonary Resection for Lung Cancer Ann. Thorac. Surg., April 1, 2009; 87(4): 995 - 1006. [Abstract] [Full Text] [PDF]
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 E. Applebaum, T. N. Ruhlen, F. R. Kronenberg, C. Hayes, and E. S. Peters Oral Cancer Knowledge, Attitudes and Practices: A Survey of Dentists and Primary Care Physicians in Massachusetts J Am Dent Assoc, April 1, 2009; 140(4): 461 - 467. [Abstract] [Full Text] [PDF]
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 C. Radecki Breitkopf and H. C. Pearson A Theory-based Approach to Understanding Follow-up of Abnormal Pap Tests J Health Psychol, April 1, 2009; 14(3): 361 - 371. [Abstract] [PDF]
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 Q. Sun, C. Liu, H. Zhong, B. Zhong, H. Xu, W. Shen, and D. Wang Multi-center Phase II Trial of Weekly Paclitaxel Plus Cisplatin Combination Chemotherapy in Patients with Advanced Gastric and Gastro-esophageal Cancer Jpn. J. Clin. Oncol., April 1, 2009; 39(4): 237 - 243. [Abstract] [Full Text] [PDF]
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 U. Kuzmanov, N. Jiang, C. R. Smith, A. Soosaipillai, and E. P. Diamandis Differential N-glycosylation of Kallikrein 6 Derived from Ovarian Cancer Cells or the Central Nervous System Mol. Cell. Proteomics, April 1, 2009; 8(4): 791 - 798. [Abstract] [Full Text] [PDF]
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X. Dong, L. Jiao, Y. Li, D. B. Evans, H. Wang, K. R. Hess, J. L. Abbruzzese, and D. Li Significant Associations of Mismatch Repair Gene Polymorphisms With Clinical Outcome of Pancreatic Cancer J. Clin. Oncol., April 1, 2009; 27(10): 1592 - 1599. [Abstract] [Full Text] [PDF]
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L. C. Vinikoor, M. D. Long, T. O. Keku, C. F. Martin, J. A. Galanko, and R. S. Sandler The Association between Diabetes, Insulin Use, and Colorectal Cancer among Whites and African Americans Cancer Epidemiol. Biomarkers Prev., April 1, 2009; 18(4): 1239 - 1242. [Abstract] [Full Text] [PDF]
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 D. Sano, S. Choi, Z. L. Milas, G. Zhou, C. E. Galer, Y.-W. Su, M. Gule, M. Zhao, Z. Zhu, and J. N. Myers The Effect of Combination Anti-Endothelial Growth Factor Receptor and Anti-Vascular Endothelial Growth Factor Receptor 2 Targeted Therapy on Lymph Node Metastasis: A Study in an Orthotopic Nude Mouse Model of Squamous Cell Carcinoma of the Oral Tongue Arch Otolaryngol Head Neck Surg, April 1, 2009; 135(4): 411 - 420. [Abstract] [Full Text] [PDF]
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J. H. Lee, E. L. Rosen, and D. A. Mankoff The Role of Radiotracer Imaging in the Diagnosis and Management of Patients with Breast Cancer: Part 1--Overview, Detection, and Staging J. Nucl. Med., April 1, 2009; 50(4): 569 - 581. [Abstract] [Full Text] [PDF]
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T. J. Wilson, K. C. Nannuru, and R. K. Singh Cathepsin G Recruits Osteoclast Precursors via Proteolytic Activation of Protease-Activated Receptor-1 Cancer Res., April 1, 2009; 69(7): 3188 - 3195. [Abstract] [Full Text] [PDF]
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R. METZGER, D. VALLBOHMER, C. MULLER-TIDOW, H. HIGASHI, E. BOLLSCHWEILER, U. WARNECKE-EBERZ, J. BRABENDER, S. E. BALDUS, H. XI, W. E. BERDEL, et al. Increased Human Telomerase Reverse Transcriptase (hTERT) mRNA Expression but not Telomerase Activity is Related to Survival in Curatively Resected Non-small Cell Lung Cancer Anticancer Res, April 1, 2009; 29(4): 1157 - 1162. [Abstract] [Full Text] [PDF]
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 D. S. Hsu, C. R. Acharya, B. S. Balakumaran, R. F. Riedel, M. K. Kim, M. Stevenson, S. Tuchman, S. Mukherjee, W. Barry, H. K. Dressman, et al. Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer PNAS, March 31, 2009; 106(13): 5312 - 5317. [Abstract] [Full Text] [PDF]
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R. Mutter, B. Lu, D. P. Carbone, I. Csiki, L. Moretti, D. H. Johnson, J. D. Morrow, A. B. Sandler, Y. Shyr, F. Ye, et al. A Phase II Study of Celecoxib in Combination with Paclitaxel, Carboplatin, and Radiotherapy for Patients with Inoperable Stage IIIA/B Non-Small Cell Lung Cancer Clin. Cancer Res., March 15, 2009; 15(6): 2158 - 2165. [Abstract] [Full Text] [PDF]
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J. S. Ko, A. H. Zea, B. I. Rini, J. L. Ireland, P. Elson, P. Cohen, A. Golshayan, P. A. Rayman, L. Wood, J. Garcia, et al. Sunitinib Mediates Reversal of Myeloid-Derived Suppressor Cell Accumulation in Renal Cell Carcinoma Patients Clin. Cancer Res., March 15, 2009; 15(6): 2148 - 2157. [Abstract] [Full Text] [PDF]
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E. W. Duiker, E. G.E. de Vries, D. Mahalingam, G. J. Meersma, W. Boersma-van Ek, H. Hollema, M. N. Lub-de Hooge, G. M. van Dam, R. H. Cool, W. J. Quax, et al. Enhanced Antitumor Efficacy of a DR5-Specific TRAIL Variant over Recombinant Human TRAIL in a Bioluminescent Ovarian Cancer Xenograft Model Clin. Cancer Res., March 15, 2009; 15(6): 2048 - 2057. [Abstract] [Full Text] [PDF]
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A. Larghi, E. C. Verna, P. G. Lecca, and G. Costamagna Screening for Pancreatic Cancer in High-Risk Individuals: A Call for Endoscopic Ultrasound Clin. Cancer Res., March 15, 2009; 15(6): 1907 - 1914. [Abstract] [Full Text] [PDF]
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S. Y. Lai, P. Koppikar, S. M. Thomas, E. E. Childs, A. M. Egloff, R. R. Seethala, B. F. Branstetter, W. E. Gooding, A. Muthukrishnan, J. M. Mountz, et al. Intratumoral Epidermal Growth Factor Receptor Antisense DNA Therapy in Head and Neck Cancer: First Human Application and Potential Antitumor Mechanisms J. Clin. Oncol., March 10, 2009; 27(8): 1235 - 1242. [Abstract] [Full Text] [PDF]
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J. W. Friedberg, M. D. Taylor, J. R. Cerhan, C. R. Flowers, H. Dillon, C. M. Farber, E. S. Rogers, J. D. Hainsworth, E. K. Wong, J. M. Vose, et al. Follicular Lymphoma in the United States: First Report of the National LymphoCare Study J. Clin. Oncol., March 10, 2009; 27(8): 1202 - 1208. [Abstract] [Full Text] [PDF]
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 L. J. Inge, K. D. Coon, M. A. Smith, and R. M. Bremner Expression of LKB1 tumor suppressor in non-small cell lung cancer determines sensitivity to 2-deoxyglucose. J. Thorac. Cardiovasc. Surg., March 1, 2009; 137(3): 580 - 586. [Abstract] [Full Text] [PDF]
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R. J. Cerfolio, A. S. Bryant, A. A. Talati, R. M. Cerfolio, and T. S. Winokur Change in maximum standardized uptake value on repeat positron emission tomography after chemoradiotherapy in patients with esophageal cancer identifies complete responders. J. Thorac. Cardiovasc. Surg., March 1, 2009; 137(3): 605 - 609. [Abstract] [Full Text] [PDF]
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 S. A Boorjian, H. V Heemers, I. Frank, S. A Farmer, L. J Schmidt, T. J Sebo, and D. J Tindall Expression and significance of androgen receptor coactivators in urothelial carcinoma of the bladder Endocr. Relat. Cancer, March 1, 2009; 16(1): 123 - 137. [Abstract] [Full Text] [PDF]
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 A. Gaikwad, J. K Wolf, J. Brown, L. M Ramondetta, and J. A Smith In vitro evaluation of the effects of gefitinib on the cytotoxic activity of selected anticancer agents in a panel of human endometrial cancer cell lines Journal of Oncology Pharmacy Practice, March 1, 2009; 15(1): 35 - 44. [Abstract] [PDF]
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 G. Lin, K.-K. Ng, C.-J. Chang, J.-J. Wang, K.-C. Ho, T.-C. Yen, T.-I Wu, C.-C. Wang, Y.-R. Chen, Y.-T. Huang, et al. Myometrial Invasion in Endometrial Cancer: Diagnostic Accuracy of Diffusion-weighted 3.0-T MR Imaging--Initial Experience Radiology, March 1, 2009; 250(3): 784 - 792. [Abstract] [Full Text] [PDF]
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B. Sen, B. Saigal, N. Parikh, G. Gallick, and F. M. Johnson Sustained Src Inhibition Results in Signal Transducer and Activator of Transcription 3 (STAT3) Activation and Cancer Cell Survival via Altered Janus-Activated Kinase-STAT3 Binding Cancer Res., March 1, 2009; 69(5): 1958 - 1965. [Abstract] [Full Text] [PDF]
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C. J. Riley, K. P. Engelhardt, J. W. Saldanha, W. Qi, L. S. Cooke, Y. Zhu, S. T. Narayan, K. Shakalya, K. D. Croce, I. G. Georgiev, et al. Design and Activity of a Murine and Humanized Anti-CEACAM6 Single-Chain Variable Fragment in the Treatment of Pancreatic Cancer Cancer Res., March 1, 2009; 69(5): 1933 - 1940. [Abstract] [Full Text] [PDF]
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AMERICAN ACADEMY OF PEDIATRICS Section on Hematolo Long-term Follow-up Care for Pediatric Cancer Survivors Pediatrics, March 1, 2009; 123(3): 906 - 915. [Abstract] [Full Text] [PDF]
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E. Sunami, M. Shinozaki, C. S. Higano, R. Wollman, T. B. Dorff, S. J. Tucker, S. R. Martinez, F. R. Singer, and D. S.B. Hoon Multimarker Circulating DNA Assay for Assessing Blood of Prostate Cancer Patients Clin. Chem., March 1, 2009; 55(3): 559 - 567. [Abstract] [Full Text] [PDF]
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A. Tanemura, A. M. Terando, M.-S. Sim, A. Q. van Hoesel, M. F.G. de Maat, D. L. Morton, and D. S.B. Hoon CpG Island Methylator Phenotype Predicts Progression of Malignant Melanoma Clin. Cancer Res., March 1, 2009; 15(5): 1801 - 1807. [Abstract] [Full Text] [PDF]
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 T. D. Sequist, A. M. Zaslavsky, R. Marshall, R. H. Fletcher, and J. Z. Ayanian Patient and Physician Reminders to Promote Colorectal Cancer Screening: A Randomized Controlled Trial Arch Intern Med, February 23, 2009; 169(4): 364 - 371. [Abstract] [Full Text] [PDF]
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 S. A. Waldman, T. Hyslop, S. Schulz, A. Barkun, K. Nielsen, J. Haaf, C. Bonaccorso, Y. Li, and D. S. Weinberg Association of GUCY2C Expression in Lymph Nodes With Time to Recurrence and Disease-Free Survival in pN0 Colorectal Cancer JAMA, February 18, 2009; 301(7): 745 - 752. [Abstract] [Full Text] [PDF]
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 C. Delloye-Bourgeois, E. Brambilla, M.-M. Coissieux, C. Guenebeaud, R. Pedeux, V. Firlej, F. Cabon, C. Brambilla, P. Mehlen, and A. Bernet Interference With Netrin-1 and Tumor Cell Death in Non-Small Cell Lung Cancer J Natl Cancer Inst, February 18, 2009; 101(4): 237 - 247. [Abstract] [Full Text] [PDF]
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