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Dr. Jemal is Strategic Director, Cancer Surveillance, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Ms. Siegel is Manager, Surveillance Information Services, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Dr. Ward is Managing Director, Surveillance Research, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Dr. Hao is Senior Epidemiologist, Surveillance Research, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Dr. Xu is Epidemiologist, Mortality Statistics Branch, Division of Vital Statistics, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD.
Mr. Murray is Manager, Surveillance Data Systems, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Dr. Thun is Vice President, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
ABSTRACT
Each year, the American Cancer Society estimates the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute, Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries and mortality data from the National Center for Health Statistics. Incidence and death rates are age-standardized to the 2000 US standard million population. A total of 1,437,180 new cancer cases and 565,650 deaths from cancer are projected to occur in the United States in 2008. Notable trends in cancer incidence and mortality include stabilization of incidence rates for all cancer sites combined in men from 1995 through 2004 and in women from 1999 through 2004 and a continued decrease in the cancer death rate since 1990 in men and since 1991 in women. Overall cancer death rates in 2004 compared with 1990 in men and 1991 in women decreased by 18.4% and 10.5%, respectively, resulting in the avoidance of over a half million deaths from cancer during this time interval. This report also examines cancer incidence, mortality, and survival by site, sex, race/ethnicity, education, geographic area, and calendar year, as well as the proportionate contribution of selected sites to the overall trends. Although much progress has been made in reducing mortality rates, stabilizing incidence rates, and improving survival, cancer still accounts for more deaths than heart disease in persons under age 85 years. Further progress can be accelerated by supporting new discoveries and by applying existing cancer control knowledge across all segments of the population.
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S. Rohrmann, C. G. Sutcliffe, J. L. Bienstock, D. Monsegue, F. Akereyeni, G. Bradwin, N. Rifai, M. N. Pollak, T. Agurs-Collins, and E. A. Platz Racial Variation in Sex Steroid Hormones and the Insulin-Like Growth Factor Axis in Umbilical Cord Blood of Male Neonates Cancer Epidemiol. Biomarkers Prev., May 1, 2009; 18(5): 1484 - 1491. [Abstract] [Full Text] [PDF]
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E. Sidelnikov, R. M. Bostick, W. D. Flanders, Q. Long, V. L. Cohen, C. Dash, M. E. Seabrook, and V. Fedirko MutL-Homolog 1 Expression and Risk of Incident, Sporadic Colorectal Adenoma: Search for Prospective Biomarkers of Risk for Colorectal Cancer Cancer Epidemiol. Biomarkers Prev., May 1, 2009; 18(5): 1599 - 1609. [Abstract] [Full Text] [PDF]
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 E.A. KOTTEAS, A. ADAMOPOULOS, P.D. DROGITIS, A. ZALONIS, K.V. GIANNOPOULOS, E.M. KARAPANAGIOTOU, M. W. SAIF, and K.N. SYRIGOS Gastrointestinal Bleeding as Initial Presentation of Melanoma of Unknown Primary Origin: Report of a Case and Review of the Literature In Vivo, May 1, 2009; 23(3): 487 - 489. [Abstract] [Full Text] [PDF]
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 M. Eisold, M. Asim, H. Eskelinen, T. Linke, and A. Baniahmad Inhibition of MAPK-signaling pathway promotes the interaction of the corepressor SMRT with the human androgen receptor and mediates repression of prostate cancer cell growth in the presence of antiandrogens J. Mol. Endocrinol., May 1, 2009; 42(5): 429 - 435. [Abstract] [Full Text] [PDF]
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M. Chen, J. Ni, H.-C. Chang, C.-Y. Lin, M. Muyan, and S. Yeh CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells Carcinogenesis, May 1, 2009; 30(5): 841 - 850. [Abstract] [Full Text] [PDF]
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M. R. Posner, C. M. Norris, L. J. Wirth, D. M. Shin, K. J. Cullen, E. W. Winquist, C. R. Blajman, E. A. Mickiewicz, G. P. Frenette, L. F. Plinar, et al. Sequential therapy for the locally advanced larynx and hypopharynx cancer subgroup in TAX 324: survival, surgery, and organ preservation Ann. Onc., May 1, 2009; 20(5): 921 - 927. [Abstract] [Full Text] [PDF]
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F. Lovat, A. Bitto, S.-Q. Xu, M. Fassan, S. Goldoni, D. Metalli, V. Wubah, P. McCue, G. Serrero, L. G. Gomella, et al. Proepithelin is an autocrine growth factor for bladder cancer Carcinogenesis, May 1, 2009; 30(5): 861 - 868. [Abstract] [Full Text] [PDF]
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J. Pan, J. Lin, J. G. Izzo, Y. Liu, J. Xing, M. Huang, J. A. Ajani, and X. Wu Genetic susceptibility to esophageal cancer: the role of the nucleotide excision repair pathway Carcinogenesis, May 1, 2009; 30(5): 785 - 792. [Abstract] [Full Text] [PDF]
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H. Hu, J. Zhang, H. J. Lee, S.-H. Kim, and J. Lu Penta-O-galloyl-beta-D-glucose induces S- and G1-cell cycle arrests in prostate cancer cells targeting DNA replication and cyclin D1 Carcinogenesis, May 1, 2009; 30(5): 818 - 823. [Abstract] [Full Text] [PDF]
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M. Dror Michaelson, M. M. Regan, W. K. Oh, D. S. Kaufman, K. Olivier, S. Z. Michaelson, B. Spicer, C. Gurski, P. W. Kantoff, and M. R. Smith Phase II study of sunitinib in men with advanced prostate cancer Ann. Onc., May 1, 2009; 20(5): 913 - 920. [Abstract] [Full Text] [PDF]
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 S. Takaishi, T. Okumura, S. Tu, S. S.W. Wang, W. Shibata, R. Vigneshwaran, S. A.K. Gordon, Y. Shimada, and T. C. Wang Identification of Gastric Cancer Stem Cells Using the Cell Surface Marker CD44 Stem Cells, May 1, 2009; 27(5): 1006 - 1020. [Abstract] [Full Text] [PDF]
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K.-T. Kuo, B. Guan, Y. Feng, T.-L. Mao, X. Chen, N. Jinawath, Y. Wang, R. J. Kurman, I.-M. Shih, and T.-L. Wang Analysis of DNA Copy Number Alterations in Ovarian Serous Tumors Identifies New Molecular Genetic Changes in Low-Grade and High-Grade Carcinomas Cancer Res., May 1, 2009; 69(9): 4036 - 4042. [Abstract] [Full Text] [PDF]
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R. Wang, D. S. Morris, S. A. Tomlins, R. J. Lonigro, A. Tsodikov, R. Mehra, T. J. Giordano, L. P. Kunju, C. T. Lee, A. Z. Weizer, et al. Development of a Multiplex Quantitative PCR Signature to Predict Progression in Non-Muscle-Invasive Bladder Cancer Cancer Res., May 1, 2009; 69(9): 3810 - 3818. [Abstract] [Full Text] [PDF]
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J. L. Watters, M. H. Gail, S. J. Weinstein, J. Virtamo, and D. Albanes Associations between {alpha}-Tocopherol, {beta}-Carotene, and Retinol and Prostate Cancer Survival Cancer Res., May 1, 2009; 69(9): 3833 - 3841. [Abstract] [Full Text] [PDF]
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Z. MORISE, A. SUGIOKA, Y. TANAHASHI, Y. OKABE, M. IKEDA, T. KAGAWA, and C. TAKEURA Treatment of Patients with Unresectable Advanced Carcinoma of Biliary Tract - Chemotherapy and Surgical Resection Anticancer Res, May 1, 2009; 29(5): 1783 - 1786. [Abstract] [Full Text] [PDF]
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 D. Y. Lim and J. H. Y. Park Induction of p53 contributes to apoptosis of HCT-116 human colon cancer cells induced by the dietary compound fisetin Am J Physiol Gastrointest Liver Physiol, May 1, 2009; 296(5): G1060 - G1068. [Abstract] [Full Text] [PDF]
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 L.-F. de Geus-Oei, D. Vriens, H. W.M. van Laarhoven, W. T.A. van der Graaf, and W. J.G. Oyen Monitoring and Predicting Response to Therapy with 18F-FDG PET in Colorectal Cancer: A Systematic Review J. Nucl. Med., May 1, 2009; 50(Suppl_1): 43S - 54S. [Abstract] [Full Text] [PDF]
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K. Kelly, J. Kittelson, W. A. Franklin, T. C. Kennedy, C. E. Klein, R. L. Keith, E. C. Dempsey, M. Lewis, M. K. Jackson, F. R. Hirsch, et al. A Randomized Phase II Chemoprevention Trial of 13-CIS Retinoic Acid with Or without {alpha} Tocopherol or Observation in Subjects at High Risk for Lung Cancer Cancer Prevention Research, May 1, 2009; 2(5): 440 - 449. [Abstract] [Full Text] [PDF]
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L. Wang, M. J.L. Bonorden, G.-x. Li, H.-J. Lee, H. Hu, Y. Zhang, J. D. Liao, M. P. Cleary, and J. Lu Methyl-Selenium Compounds Inhibit Prostate Carcinogenesis in the Transgenic Adenocarcinoma of Mouse Prostate Model with Survival Benefit Cancer Prevention Research, May 1, 2009; 2(5): 484 - 495. [Abstract] [Full Text] [PDF]
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L. Vitale-Cross, R. Czerninski, P. Amornphimoltham, V. Patel, A. A. Molinolo, and J. S. Gutkind Chemical Carcinogenesis Models for Evaluating Molecular-Targeted Prevention and Treatment of Oral Cancer Cancer Prevention Research, May 1, 2009; 2(5): 419 - 422. [Full Text] [PDF]
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G. J. Kelloff, C. C. Sigman, and C. H. Contag Early Detection of Oral Neoplasia: Watching with New Eyes Cancer Prevention Research, May 1, 2009; 2(5): 405 - 408. [Full Text] [PDF]
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 Y. Su, K. Shankar, and R. C. M. Simmen Early Soy Exposure via Maternal Diet Regulates Rat Mammary Epithelial Differentiation by Paracrine Signaling from Stromal Adipocytes J. Nutr., May 1, 2009; 139(5): 945 - 951. [Abstract] [Full Text] [PDF]
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D. G. Power and N. E. Kemeny The role of floxuridine in metastatic liver disease Mol. Cancer Ther., May 1, 2009; 8(5): 1015 - 1025. [Abstract] [Full Text] [PDF]
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G. Lurje, P. C. Manegold, Y. Ning, A. Pohl, W. Zhang, and H.-J. Lenz Thymidylate synthase gene variations: predictive and prognostic markers Mol. Cancer Ther., May 1, 2009; 8(5): 1000 - 1007. [Abstract] [Full Text] [PDF]
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L. Moretti, K. W. Kim, D. K. Jung, C. D. Willey, and B. Lu Radiosensitization of solid tumors by Z-VAD, a pan-caspase inhibitor Mol. Cancer Ther., May 1, 2009; 8(5): 1270 - 1279. [Abstract] [Full Text] [PDF]
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D. J. Vander Griend, L. Antony, S. L. Dalrymple, Y. Xu, S. B. Christensen, S. R. Denmeade, and J. T. Isaacs Amino acid containing thapsigargin analogues deplete androgen receptor protein via synthesis inhibition and induce the death of prostate cancer cells Mol. Cancer Ther., May 1, 2009; 8(5): 1340 - 1349. [Abstract] [Full Text] [PDF]
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D. Z. Qian, C.-Y. Huang, C. A. O'Brien, I. M. Coleman, M. Garzotto, L. D. True, C. S. Higano, R. Vessella, P. H. Lange, P. S. Nelson, et al. Prostate Cancer-Associated Gene Expression Alterations Determined from Needle Biopsies Clin. Cancer Res., May 1, 2009; 15(9): 3135 - 3142. [Abstract] [Full Text] [PDF]
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S. T. Huyn, J. B. Burton, M. Sato, M. Carey, S. S. Gambhir, and L. Wu A Potent, Imaging Adenoviral Vector Driven by the Cancer-selective Mucin-1 Promoter That Targets Breast Cancer Metastasis Clin. Cancer Res., May 1, 2009; 15(9): 3126 - 3134. [Abstract] [Full Text] [PDF]
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G. Liu, W. K. Kelly, G. Wilding, L. Leopold, K. Brill, and B. Somer An Open-Label, Multicenter, Phase I/II Study of Single-Agent AT-101 in Men with Castrate-Resistant Prostate Cancer Clin. Cancer Res., May 1, 2009; 15(9): 3172 - 3176. [Abstract] [Full Text] [PDF]
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