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TABLE 9 Integrin Targeting Agents
Agents Targets Trial Stage
Monoclonal antibodies
 Volociximab {alpha}5β1 Phase II (nonsmall cell lung, melanoma, pancreatic)
 Vitaxin {alpha}vβ3 Phase II (colorectal, melanoma, renal)
 CNTO-95 {alpha}v Phase I
Peptide inhibitors
 Cilengitide  (EMD-121974) {alpha}vβ3 Phase II (brain, head and neck, leukemia, melanoma, prostate)
 E-7820 {alpha}2 Phase I
Peptidomimetics
 S247 {alpha}vβ3 Preclinical





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