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Dr. Jemal is Strategic Director, Cancer Surveillance, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Ms. Siegel is Manager, Surveillance Information Services, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Dr. Ward is Managing Director, Surveillance Research, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Dr. Hao is Senior Epidemiologist, Surveillance Research, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Dr. Xu is Epidemiologist, Mortality Statistics Branch, Division of Vital Statistics, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD.
Mr. Murray is Manager, Surveillance Data Systems, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Dr. Thun is Vice President, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Published online through CA First Look at http://CAonline.AmCancerSoc.org.
Each year, the American Cancer Society estimates the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute, Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries and mortality data from the National Center for Health Statistics. Incidence and death rates are age-standardized to the 2000 US standard million population. A total of 1,437,180 new cancer cases and 565,650 deaths from cancer are projected to occur in the United States in 2008. Notable trends in cancer incidence and mortality include stabilization of incidence rates for all cancer sites combined in men from 1995 through 2004 and in women from 1999 through 2004 and a continued decrease in the cancer death rate since 1990 in men and since 1991 in women. Overall cancer death rates in 2004 compared with 1990 in men and 1991 in women decreased by 18.4% and 10.5%, respectively, resulting in the avoidance of over a half million deaths from cancer during this time interval. This report also examines cancer incidence, mortality, and survival by site, sex, race/ethnicity, education, geographic area, and calendar year, as well as the proportionate contribution of selected sites to the overall trends. Although much progress has been made in reducing mortality rates, stabilizing incidence rates, and improving survival, cancer still accounts for more deaths than heart disease in persons under age 85 years. Further progress can be accelerated by supporting new discoveries and by applying existing cancer control knowledge across all segments of the population.
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S.-H. WU, L.-W. HANG, J.-S. YANG, H.-Y. CHEN, H.-Y. LIN, J.-H. CHIANG, C.-C. LU, J.-L. YANG, T.-Y. LAI, Y.-C. KO, et al. Curcumin Induces Apoptosis in Human Non-small Cell Lung Cancer NCI-H460 Cells through ER Stress and Caspase Cascade- and Mitochondria-dependent Pathways Anticancer Res, June 1, 2010; 30(6): 2125 - 2133. [Abstract] [Full Text] [PDF]
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F. LIN, K. LIN, X. XIE, and C. ZHOU Increased ERCC1 Protein Expression Is Associated with Suboptimal Debulking in Advanced Epithelial Ovarian Cancer Anticancer Res, June 1, 2010; 30(6): 2447 - 2452. [Abstract] [Full Text] [PDF]
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D. J. Yoon, B. H. Kwan, F. C. Chao, T. P. Nicolaides, J. J. Phillips, G. Y. Lam, A. B. Mason, W. A. Weiss, and D. T. Kamei Intratumoral Therapy of Glioblastoma Multiforme Using Genetically Engineered Transferrin for Drug Delivery Cancer Res., June 1, 2010; 70(11): 4520 - 4527. [Abstract] [Full Text] [PDF]
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G. Feldmann, A. Mishra, S.-M. Hong, S. Bisht, C. J. Strock, D. W. Ball, M. Goggins, A. Maitra, and B. D. Nelkin Inhibiting the Cyclin-Dependent Kinase CDK5 Blocks Pancreatic Cancer Formation and Progression through the Suppression of Ras-Ral Signaling Cancer Res., June 1, 2010; 70(11): 4460 - 4469. [Abstract] [Full Text] [PDF]
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S.-H. Kim and S. V. Singh p53-Independent Apoptosis by Benzyl Isothiocyanate in Human Breast Cancer Cells Is Mediated by Suppression of XIAP Expression Cancer Prevention Research, June 1, 2010; 3(6): 718 - 726. [Abstract] [Full Text] [PDF]
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J. J. Lee, L. Feng, D. S. Reshef, A. L. Sabichi, B. Williams, W. Rinsurongkawong, I. I. Wistuba, R. Lotan, and S. M. Lippman Mortality in the Randomized, Controlled Lung Intergroup Trial of Isotretinoin Cancer Prevention Research, June 1, 2010; 3(6): 738 - 744. [Abstract] [Full Text] [PDF]
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J. Nautiyal, Y. Yu, A. Aboukameel, S. S. Kanwar, J. K. Das, J. Du, B. B. Patel, F. H. Sarkar, A. K. Rishi, R. M. Mohammad, et al. ErbB-Inhibitory Protein: A Modified Ectodomain of Epidermal Growth Factor Receptor Synergizes with Dasatinib to Inhibit Growth of Breast Cancer Cells Mol. Cancer Ther., June 1, 2010; 9(6): 1503 - 1514. [Abstract] [Full Text] [PDF]
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C. Wang, C. M. Michener, J. L. Belinson, S. Vaziri, R. Ganapathi, and S. Sengupta Role of the 18:1 Lysophosphatidic Acid-Ovarian Cancer Immunoreactive Antigen Domain Containing 1 (OCIAD1)-Integrin Axis in Generating Late-Stage Ovarian Cancer Mol. Cancer Ther., June 1, 2010; 9(6): 1709 - 1718. [Abstract] [Full Text] [PDF]
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E. Van Cutsem, M. Dicato, N. Arber, J. Berlin, A. Cervantes, F. Ciardiello, A. De Gramont, E. Diaz-Rubio, M. Ducreux, R. Geva, et al. Molecular markers and biological targeted therapies in metastatic colorectal cancer: expert opinion and recommendations derived from the 11th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2009 Ann. Onc., June 1, 2010; 21(suppl_6): vi1 - vi10. [Abstract] [Full Text] [PDF]
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J. M. Weiss, S. Attia, H. H. Bailey, S. Weber, J. Hu, M. Reichelderfer, and D. V. Gopal Metastatic Soft Tissue Sarcoma Diagnosed by Small Bowel Video Capsule Endoscopy J. Clin. Oncol., May 20, 2010; 28(15): e233 - e235. [Full Text] [PDF]
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J. Peppercorn, I. Shapira, D. Collyar, T. Deshields, N. Lin, I. Krop, H. Grunwald, P. Friedman, A. H. Partridge, R. L. Schilsky, et al. Ethics of Mandatory Research Biopsy for Correlative End Points Within Clinical Trials in Oncology J. Clin. Oncol., May 20, 2010; 28(15): 2635 - 2640. [Abstract] [Full Text] [PDF]
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M. J. Overman, D. M. Maru, C. Charnsangavej, E. M. Loyer, H. Wang, P. Pathak, C. Eng, P. M. Hoff, J. N. Vauthey, R. A. Wolff, et al. Oxaliplatin-Mediated Increase in Spleen Size As a Biomarker for the Development of Hepatic Sinusoidal Injury J. Clin. Oncol., May 20, 2010; 28(15): 2549 - 2555. [Abstract] [Full Text] [PDF]
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E. Amir, O. C. Freedman, B. Seruga, and D. G. Evans Assessing Women at High Risk of Breast Cancer: A Review of Risk Assessment Models J Natl Cancer Inst, May 19, 2010; 102(10): 680 - 691. [Abstract] [Full Text] [PDF]
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W. G. Hocking, P. Hu, M. M. Oken, S. D. Winslow, P. A. Kvale, P. C. Prorok, L. R. Ragard, J. Commins, D. A. Lynch, G. L. Andriole, et al. Lung Cancer Screening in the Randomized Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial J Natl Cancer Inst, May 19, 2010; 102(10): 722 - 731. [Abstract] [Full Text] [PDF]
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 S. A. Kavanaugh, L. A. White, and J. M. Kolesar Vorinostat: A novel therapy for the treatment of cutaneous T-cell lymphoma Am. J. Health Syst. Pharm., May 15, 2010; 67(10): 793 - 797. [Abstract] [Full Text] [PDF]
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M. F. G. de Maat, C. J. H. van de Velde, A. Benard, H. Putter, H. Morreau, J. H. J. M. van Krieken, E. Meershoek Klein-Kranenbarg, E. J. de Graaf, R. A. E. M. Tollenaar, and D. S. B. Hoon Identification of a Quantitative MINT Locus Methylation Profile Predicting Local Regional Recurrence of Rectal Cancer Clin. Cancer Res., May 15, 2010; 16(10): 2811 - 2818. [Abstract] [Full Text] [PDF]
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 M. F. Kaminski, J. Regula, E. Kraszewska, M. Polkowski, U. Wojciechowska, J. Didkowska, M. Zwierko, M. Rupinski, M. P. Nowacki, and E. Butruk Quality Indicators for Colonoscopy and the Risk of Interval Cancer N. Engl. J. Med., May 13, 2010; 362(19): 1795 - 1803. [Abstract] [Full Text] [PDF]
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B. K. Yoo, L. Emdad, R. Gredler, C. Fuller, C. I. Dumur, K. H. Jones, C. Jackson-Cook, Z.-z. Su, D. Chen, U. H. Saxena, et al. Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma PNAS, May 4, 2010; 107(18): 8357 - 8362. [Abstract] [Full Text] [PDF]
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J. Sehouli, K. Pietzner, P. Harter, K. Munstedt, S. Mahner, A. Hasenburg, O. Camara, P. Wimberger, D. Boehmer, K. J. Buehling, et al. Prognostic role of platinum sensitivity in patients with brain metastases from ovarian cancer: results of a German multicenter study Ann. Onc., May 3, 2010; (2010) mdq229v1. [Abstract] [Full Text] [PDF]
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 S. Yao, A. Bee, D. Brewer, A. Dodson, C. Beesley, Y. Ke, L. Ambroisine, G. Fisher, H. Moller, T. Dickinson, et al. PRKC-{zeta} Expression Promotes the Aggressive Phenotype of Human Prostate Cancer Cells and Is a Novel Target for Therapeutic Intervention Genes & Cancer, May 1, 2010; 1(5): 444 - 464. [Abstract] [Full Text] [PDF]
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J. K. Kirui, Y. Xie, D. W. Wolff, H. Jiang, P. W. Abel, and Y. Tu G{beta}{gamma} Signaling Promotes Breast Cancer Cell Migration and Invasion J. Pharmacol. Exp. Ther., May 1, 2010; 333(2): 393 - 403. [Abstract] [Full Text] [PDF]
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D. R. Spigel, F. A. Greco, A. A. Meluch, C. M. Lane, C. Farley, J. R. Gray, B. L. Clark, H. A. Burris III, and J. D. Hainsworth Phase I/II Trial of Preoperative Oxaliplatin, Docetaxel, and Capecitabine With Concurrent Radiation Therapy in Localized Carcinoma of the Esophagus or Gastroesophageal Junction J. Clin. Oncol., May 1, 2010; 28(13): 2213 - 2219. [Abstract] [Full Text] [PDF]
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Z. Yurkovetsky, S. Skates, A. Lomakin, B. Nolen, T. Pulsipher, F. Modugno, J. Marks, A. Godwin, E. Gorelik, I. Jacobs, et al. Development of a Multimarker Assay for Early Detection of Ovarian Cancer J. Clin. Oncol., May 1, 2010; 28(13): 2159 - 2166. [Abstract] [Full Text] [PDF]
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M. Gupta, D. R. Berk, C. Gray, L. A. Cornelius, and S. J. Bayliss Morphologic Features and Natural History of Scalp Nevi in Children Arch Dermatol, May 1, 2010; 146(5): 506 - 511. [Abstract] [Full Text] [PDF]
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 C. Torre, S. J. Wang, W. Xia, and L. Y. W. Bourguignon Reduction of Hyaluronan-CD44-Mediated Growth, Migration, and Cisplatin Resistance in Head and Neck Cancer Due to Inhibition of Rho Kinase and PI-3 Kinase Signaling Arch Otolaryngol Head Neck Surg, May 1, 2010; 136(5): 493 - 501. [Abstract] [Full Text] [PDF]
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Z. Zhou, T. P. McDade, J. P. Simons, S. C. Ng, L. A. Lambert, G. F. Whalen, S. A. Shah, and J. F. Tseng Surgery and Radiotherapy for Retroperitoneal and Abdominal Sarcoma: Both Necessary and Sufficient Arch Surg, May 1, 2010; 145(5): 426 - 431. [Abstract] [Full Text] [PDF]
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M. Solanas, L. Grau, R. Moral, E. Vela, R. Escrich, and E. Escrich Dietary olive oil and corn oil differentially affect experimental breast cancer through distinct modulation of the p21Ras signaling and the proliferation-apoptosis balance Carcinogenesis, May 1, 2010; 31(5): 871 - 879. [Abstract] [Full Text] [PDF]
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S. M. Langevin, R. A. Stone, C. H. Bunker, J. R. Grandis, R. W. Sobol, and E. Taioli MicroRNA-137 promoter methylation in oral rinses from patients with squamous cell carcinoma of the head and neck is associated with gender and body mass index Carcinogenesis, May 1, 2010; 31(5): 864 - 870. [Abstract] [Full Text] [PDF]
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X. S. Chen, X. Q. Nie, C. M. Chen, J. Y. Wu, J. Wu, J. S. Lu, Z. M. Shao, Z. Z. Shen, and K. W. Shen Weekly paclitaxel plus carboplatin is an effective nonanthracycline-containing regimen as neoadjuvant chemotherapy for breast cancer Ann. Onc., May 1, 2010; 21(5): 961 - 967. [Abstract] [Full Text] [PDF]
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Y. Ning, R. B. Riggins, J. E. Mulla, H. Chung, A. Zwart, and R. Clarke IFN{gamma} Restores Breast Cancer Sensitivity to Fulvestrant by Regulating STAT1, IFN Regulatory Factor 1, NF-{kappa}B, BCL2 Family Members, and Signaling to Caspase-Dependent Apoptosis Mol. Cancer Ther., May 1, 2010; 9(5): 1274 - 1285. [Abstract] [Full Text] [PDF]
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 V. S. Nair, P. G. Barnett, L. Ananth, M. K. Gould, and for the Veterans Affairs Solitary Nodule Accuracy PET Scan 18F-Fluorodeoxyglucose Uptake and Prognosis in Patients With Resected Clinical Stage IA Non-small Cell Lung Cancer Chest, May 1, 2010; 137(5): 1150 - 1156. [Abstract] [Full Text] [PDF]
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 M. Hussein, J. R. Berenson, R. Niesvizky, N. Munshi, J. Matous, R. Sobecks, K. Harrop, J. G. Drachman, and N. Whiting A phase I multidose study of dacetuzumab (SGN-40; humanized anti-CD40 monoclonal antibody) in patients with multiple myeloma Haematologica, May 1, 2010; 95(5): 845 - 848. [Abstract] [Full Text] [PDF]
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M. P. Torres, M. P. Ponnusamy, S. Chakraborty, L. M. Smith, S. Das, H. A. Arafat, and S. K. Batra Effects of Thymoquinone in the Expression of Mucin 4 in Pancreatic Cancer Cells: Implications for the Development of Novel Cancer Therapies Mol. Cancer Ther., May 1, 2010; 9(5): 1419 - 1431. [Abstract] [Full Text] [PDF]
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