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Published online before print February 20, 2008
CA Cancer J Clin 2008; 58:71-96
doi: 10.3322/CA.2007.0010
© 2008 American Cancer Society
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Cancer Statistics, 2008

Ahmedin Jemal, DVM, PhD, Rebecca Siegel, MPH, Elizabeth Ward, PhD, Yongping Hao, PhD, Jiaquan Xu, MD*, Taylor Murray and Michael J. Thun, MD, MS

Dr. Jemal is Strategic Director, Cancer Surveillance, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Ms. Siegel is Manager, Surveillance Information Services, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Dr. Ward is Managing Director, Surveillance Research, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Dr. Hao is Senior Epidemiologist, Surveillance Research, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Dr. Xu is Epidemiologist, Mortality Statistics Branch, Division of Vital Statistics, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD.
Mr. Murray is Manager, Surveillance Data Systems, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.
Dr. Thun is Vice President, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA.

Published online through CA First Look at http://CAonline.AmCancerSoc.org.

Each year, the American Cancer Society estimates the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute, Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries and mortality data from the National Center for Health Statistics. Incidence and death rates are age-standardized to the 2000 US standard million population. A total of 1,437,180 new cancer cases and 565,650 deaths from cancer are projected to occur in the United States in 2008. Notable trends in cancer incidence and mortality include stabilization of incidence rates for all cancer sites combined in men from 1995 through 2004 and in women from 1999 through 2004 and a continued decrease in the cancer death rate since 1990 in men and since 1991 in women. Overall cancer death rates in 2004 compared with 1990 in men and 1991 in women decreased by 18.4% and 10.5%, respectively, resulting in the avoidance of over a half million deaths from cancer during this time interval. This report also examines cancer incidence, mortality, and survival by site, sex, race/ethnicity, education, geographic area, and calendar year, as well as the proportionate contribution of selected sites to the overall trends. Although much progress has been made in reducing mortality rates, stabilizing incidence rates, and improving survival, cancer still accounts for more deaths than heart disease in persons under age 85 years. Further progress can be accelerated by supporting new discoveries and by applying existing cancer control knowledge across all segments of the population.




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Z. Jia, Y. Gao, L. Wang, Q. Li, J. Zhang, X. Le, D. Wei, J. C. Yao, D. Z. Chang, S. Huang, et al.
Combined Treatment of Pancreatic Cancer with Mithramycin A and Tolfenamic Acid Promotes Sp1 Degradation and Synergistic Antitumor Activity
Cancer Res., February 1, 2010; 70(3): 1111 - 1119.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
J. Logan-Collins, R. M. Thomas, P. Yu, D. Jaquish, E. Mose, R. French, W. Stuart, R. McClaine, B. Aronow, R. M. Hoffman, et al.
Silencing of RON Receptor Signaling Promotes Apoptosis and Gemcitabine Sensitivity in Pancreatic Cancers
Cancer Res., February 1, 2010; 70(3): 1130 - 1140.
[Abstract] [Full Text] [PDF]

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 Am J EpidemiolHome page
X. Ma, Y. Park, S. T. Mayne, R. Wang, R. Sinha, A. R. Hollenbeck, A. Schatzkin, and A. J. Cross
Diet, Lifestyle, and Acute Myeloid Leukemia in the NIH-AARP Cohort
Am. J. Epidemiol., February 1, 2010; 171(3): 312 - 322.
[Abstract] [Full Text] [PDF]

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 Cancer Prevention ResearchHome page
C. Li, J. Lu, Z. Liu, L.-E. Wang, H. Zhao, A. K. El-Naggar, E. M. Sturgis, and Q. Wei
The Six-Nucleotide Deletion/Insertion Variant in the CASP8 Promoter Region Is Inversely Associated with Risk of Squamous Cell Carcinoma of the Head and Neck
Cancer Prevention Research, February 1, 2010; 3(2): 246 - 253.
[Abstract] [Full Text] [PDF]

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 Cancer Prevention ResearchHome page
E. S. Kim, W. K. Hong, J. J. Lee, L. Mao, R. C. Morice, D. D. Liu, C. A. Jimenez, G. A. Eapen, R. Lotan, X. Tang, et al.
Biological Activity of Celecoxib in the Bronchial Epithelium of Current and Former Smokers
Cancer Prevention Research, February 1, 2010; 3(2): 148 - 159.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
S. M. Keefe, M. A. Cohen, and M. S. Brose
Targeting Vascular Endothelial Growth Factor Receptor in Thyroid Cancer: The Intracellular and Extracellular Implications
Clin. Cancer Res., February 1, 2010; 16(3): 778 - 783.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
S. Boeck, M. Haas, R. P. Laubender, F. Kullmann, C. Klose, C. J. Bruns, R. Wilkowski, P. Stieber, S. Holdenrieder, H. Buchner, et al.
Application of a Time-Varying Covariate Model to the Analysis of CA 19-9 as Serum Biomarker in Patients with Advanced Pancreatic Cancer
Clin. Cancer Res., February 1, 2010; 16(3): 986 - 994.
[Abstract] [Full Text] [PDF]

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 Endocr Relat CancerHome page
A. V Krishnan and D. Feldman
Molecular pathways mediating the anti-inflammatory effects of calcitriol: implications for prostate cancer chemoprevention and treatment
Endocr. Relat. Cancer, January 29, 2010; 17(1): R19 - R38.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
K. E. Hung, M. A. Maricevich, L. G. Richard, W. Y. Chen, M. P. Richardson, A. Kunin, R. T. Bronson, U. Mahmood, and R. Kucherlapati
Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment
PNAS, January 26, 2010; 107(4): 1565 - 1570.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
L.-E Wang, Z. Hu, E. M. Sturgis, M. R. Spitz, S. S. Strom, C. I. Amos, Z. Guo, Y. Qiao, A. M. Gillenwater, J. N. Myers, et al.
Reduced DNA Repair Capacity for Removing Tobacco Carcinogen-Induced DNA Adducts Contributes to Risk of Head and Neck Cancer but not Tumor Characteristics
Clin. Cancer Res., January 15, 2010; 16(2): 764 - 774.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
R. S. Finn
Development of Molecularly Targeted Therapies in Hepatocellular Carcinoma: Where Do We Go Now?
Clin. Cancer Res., January 15, 2010; 16(2): 390 - 397.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
D. Beleford, Z. Liu, R. Rattan, L. Quagliuolo, M. Boccellino, A. Baldi, J. Maguire, J. Staub, J. Molina, and V. Shridhar
Methylation Induced Gene Silencing of HtrA3 in Smoking-Related Lung Cancer
Clin. Cancer Res., January 15, 2010; 16(2): 398 - 409.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
N. Rasool, W. LaRochelle, H. Zhong, G. Ara, J. Cohen, and E. C. Kohn
Secretory Leukocyte Protease Inhibitor Antagonizes Paclitaxel in Ovarian Cancer Cells
Clin. Cancer Res., January 15, 2010; 16(2): 600 - 609.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
J. Du, S. M. Martin, M. Levine, B. A. Wagner, G. R. Buettner, S.-h. Wang, A. F. Taghiyev, C. Du, C. M. Knudson, and J. J. Cullen
Mechanisms of Ascorbate-Induced Cytotoxicity in Pancreatic Cancer
Clin. Cancer Res., January 15, 2010; 16(2): 509 - 520.
[Abstract] [Full Text] [PDF]

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 Ann OncolHome page
L.-R. He, H.-Y. Zhao, B.-K. Li, L.-J. Zhang, M.-Z. Liu, H.-F. Kung, X.-Y. Guan, X.-W. Bian, Y.-X. Zeng, and D. Xie
Overexpression of AIB1 negatively affects survival of surgically resected non-small-cell lung cancer patients
Ann. Onc., January 11, 2010; (2010) mdp592v1.
[Abstract] [Full Text] [PDF]

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 JCOHome page
A. Kutikov, B. L. Egleston, Y.-N. Wong, and R. G. Uzzo
Evaluating Overall Survival and Competing Risks of Death in Patients With Localized Renal Cell Carcinoma Using a Comprehensive Nomogram
J. Clin. Oncol., January 10, 2010; 28(2): 311 - 317.
[Abstract] [Full Text] [PDF]

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 JCOHome page
W. F. Anderson, I. Jatoi, J. Tse, and P. S. Rosenberg
Male Breast Cancer: A Population-Based Comparison With Female Breast Cancer
J. Clin. Oncol., January 10, 2010; 28(2): 232 - 239.
[Abstract] [Full Text] [PDF]

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 Cancer Epidemiol. Biomarkers Prev.Home page
E. J. Whitman, M. Pomerantz, Y. Chen, M. M. Chamberlin, B. Furusato, C. Gao, A. Ali, L. Ravindranath, A. Dobi, I. A. Sestrehenn, et al.
Prostate Cancer Risk Allele Specific for African Descent Associates with Pathologic Stage at Prostatectomy
Cancer Epidemiol. Biomarkers Prev., January 1, 2010; 19(1): 1 - 8.
[Abstract] [Full Text] [PDF]

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 Cancer Epidemiol. Biomarkers Prev.Home page
J. Jayachandran, W. J. Aronson, M. K. Terris, J. C. Presti Jr., C. L. Amling, C. J. Kane, and S. J. Freedland
Diabetes and Outcomes After Radical Prostatectomy: Are Results Affected by Obesity and Race? Results from the Shared Equal-Access Regional Cancer Hospital Database
Cancer Epidemiol. Biomarkers Prev., January 1, 2010; 19(1): 9 - 17.
[Abstract] [Full Text] [PDF]

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 Cancer Epidemiol. Biomarkers Prev.Home page
W. J. Langeberg, E. M. Kwon, J. S. Koopmeiners, E. A. Ostrander, and J. L. Stanford
Population-Based Study of the Association of Variants in Mismatch Repair Genes with Prostate Cancer Risk and Outcomes
Cancer Epidemiol. Biomarkers Prev., January 1, 2010; 19(1): 258 - 264.
[Abstract] [Full Text] [PDF]

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 JCOHome page
G. D. Goss, A. Arnold, F. A. Shepherd, M. Dediu, T.-E. Ciuleanu, D. Fenton, M. Zukin, D. Walde, F. Laberge, M. D. Vincent, et al.
Randomized, Double-Blind Trial of Carboplatin and Paclitaxel With Either Daily Oral Cediranib or Placebo in Advanced Non-Small-Cell Lung Cancer: NCIC Clinical Trials Group BR24 Study
J. Clin. Oncol., January 1, 2010; 28(1): 49 - 55.
[Abstract] [Full Text] [PDF]

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 Exp Biol MedHome page
A. Hsu, T. M Bray, W. G Helferich, D. R Doerge, and E. Ho
Differential effects of whole soy extract and soy isoflavones on apoptosis in prostate cancer cells
Exp Biol Med, January 1, 2010; 235(1): 90 - 97.
[Abstract] [Full Text] [PDF]

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 Jpn J Clin OncolHome page
R. Zhao, J. Zhu, X. Ji, J. Cai, F. Wan, Q. Li, B. Zhong, S. Tucker, and D. Wang
A Phase II Study of Irinotecan and Capecitabine for Patients with Unresectable Liver-only Metastases from Colorectal Cancer
Jpn. J. Clin. Oncol., January 1, 2010; 40(1): 10 - 16.
[Abstract] [Full Text] [PDF]

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 JCOHome page
H. R. Alexander Jr, D. L. Fraker, D. L. Bartlett, S. K. Libutti, S. M. Steinberg, P. Soriano, and T. Beresnev
Analysis of Factors Influencing Outcome in Patients With In-Transit Malignant Melanoma Undergoing Isolated Limb Perfusion Using Modern Treatment Parameters
J. Clin. Oncol., January 1, 2010; 28(1): 114 - 118.
[Abstract] [Full Text] [PDF]

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 Mol. Endocrinol.Home page
C. D. DuSell, E. R. Nelson, B. M. Wittmann, J. A. Fretz, D. Kazmin, R. S. Thomas, J. W. Pike, and D. P. McDonnell
Regulation of Aryl Hydrocarbon Receptor Function by Selective Estrogen Receptor Modulators
Mol. Endocrinol., January 1, 2010; 24(1): 33 - 46.
[Abstract] [Full Text] [PDF]

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 Therapeutic Advances in Medical OncologyHome page
D. Y.C. Heng, C. Kollmannsberger, and K. N. Chi
Review: Targeted therapy for metastatic renal cell carcinoma: current treatment and future directions
Therapeutic Advances in Medical Oncology, January 1, 2010; 2(1): 39 - 49.
[Abstract] [PDF]

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 Therapeutic Advances in Medical OncologyHome page
A. K. Agarwala and N. H. Hanna
Review: Advanced non-small cell lung cancer: the role of maintenance therapy
Therapeutic Advances in Medical Oncology, January 1, 2010; 2(1): 17 - 23.
[Abstract] [PDF]

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 CA Cancer J ClinHome page
M. Kagawa-Singer, A. Valdez Dadia, M. C. Yu, and A. Surbone
Cancer, Culture, and Health Disparities: Time to Chart a New Course?
CA Cancer J Clin, January 1, 2010; 60(1): 12 - 39.
[Abstract] [Full Text] [PDF]

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 Arch DermatolHome page
J. K. Robinson, R. Turrisi, K. Mallett, J. Stapleton, and M. Pion
Comparing the Efficacy of an In-Person Intervention With a Skin Self-examination Workbook
Arch Dermatol, January 1, 2010; 146(1): 91 - 94.
[Full Text] [PDF]

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 Arch SurgHome page
R. Yang, M. C. Cheung, M. M. Byrne, X. Jin, A. J. Montero, C. Jones, and L. G. Koniaris
Survival Effects of Adjuvant Chemoradiotherapy After Resection for Pancreatic Carcinoma
Arch Surg, January 1, 2010; 145(1): 49 - 56.
[Abstract] [Full Text] [PDF]

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 Cancer Prevention ResearchHome page
H. H. Bailey, K. Kim, A. K. Verma, K. Sielaff, P. O. Larson, S. Snow, T. Lenaghan, J. L. Viner, J. Douglas, N. E. Dreckschmidt, et al.
A Randomized, Double-Blind, Placebo-Controlled Phase 3 Skin Cancer Prevention Study of {alpha}-Difluoromethylornithine in Subjects with Previous History of Skin Cancer
Cancer Prevention Research, January 1, 2010; 3(1): 35 - 47.
[Abstract] [Full Text] [PDF]


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