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This Article Full Text Full Text (PDF) CME: Take the course for this article: Cutaneous Manifestations of Internal Malignancy FREE NURSING CONTACT HOURS All Versions of this Article: caac.20005v1 59/2/73    most recent Submit a letter to the editor View responses Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Thiers, B. H. Articles by Callen, J. P. Search for Related Content PubMed PubMed Citation Articles by Thiers, B. H. Articles by Callen, J. P.

Cutaneous Manifestations of Internal Malignancy

¹Professor of Dermatology and Chair, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, SC
²College of Medicine, Medical University of South Carolina, Charleston, SC
³Professor of Medicine and Chief, Division of Dermatology, University of Louisville School of Medicine, Louisville, KY

Corresponding author: Bruce H. Thiers, MD, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, 135 Rutledge Avenue, 11th Floor, PO Box 250578, Charleston, SC 29425; e-mail: thiersb{at}musc.edu

To earn free CME credit or nursing contact hours for successfully completing the online quiz based on this article, go to http://CME.AmCancerSoc.org.

DISCLOSURES: The authors report no conflicts of interest.

The skin often mirrors changes in the organism it envelops. Many neoplastic diseases that affect internal organs display cutaneous manifestations, which may be the presenting signs and symptoms of the underlying malignancy. These may reflect direct involvement of the skin by the tumor (ie, tumor metastasis) or indirect involvement, in which changes in the skin occur in the absence of malignant cells. This review focuses on the latter conditions, which are often referred to as paraneoplastic dermatoses. Included in the discussion are the cutaneous manifestations of inherited syndromes that are associated with an increased risk of internal malignancy, cutaneous changes in patients with hormone-secreting tumors, and the wide spectrum of proliferative and inflammatory dermatoses that have been associated with internal cancer. CA Cancer J Clin 2009;59:73–98. © 2009 American Cancer Society, Inc.

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