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1Strategic Director, Cancer Surveillance, Surveillance and Health Policy Research, American Cancer Society, Atlanta, Georgia
2Manager, Surveillance Information Services, Surveillance and Health Policy Research, American Cancer Society, Atlanta, Georgia
3Vice President, Surveillance and Health Policy Research, American Cancer Society, Atlanta, Georgia
4Senior Epidemiologist, Surveillance and Health Policy Research, American Cancer Society, Atlanta, Georgia
5Epidemiologist, Mortality Statistics Branch, Division of Vital Statistics, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland
6Vice President Emeritus, Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia
Corresponding author: Ahmedin Jemal, DVM, PhD, Surveillance and Health Policy Research, American Cancer Society, 250 Williams Street, NW, Atlanta, GA 30303-1002; ahmedin.jemal{at}cancer.org
DISCLOSURES: The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. The authors report no conflicts of interest.
Each year, the American Cancer Society estimates the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute, Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries and mortality data from the National Center for Health Statistics. Incidence and death rates are standardized by age to the 2000 United States standard million population. A total of 1,479,350 new cancer cases and 562,340 deaths from cancer are projected to occur in the United States in 2009. Overall cancer incidence rates decreased in the most recent time period in both men (1.8% per year from 2001 to 2005) and women (0.6% per year from 1998 to 2005), largely because of decreases in the three major cancer sites in men (lung, prostate, and colon and rectum [colorectum]) and in two major cancer sites in women (breast and colorectum). Overall cancer death rates decreased in men by 19.2% between 1990 and 2005, with decreases in lung (37%), prostate (24%), and colorectal (17%) cancer rates accounting for nearly 80% of the total decrease. Among women, overall cancer death rates between 1991 and 2005 decreased by 11.4%, with decreases in breast (37%) and colorectal (24%) cancer rates accounting for 60% of the total decrease. The reduction in the overall cancer death rates has resulted in the avoidance of about 650,000 deaths from cancer over the 15-year period. This report also examines cancer incidence, mortality, and survival by site, sex, race/ethnicity, education, geographic area, and calendar year. Although progress has been made in reducing incidence and mortality rates and improving survival, cancer still accounts for more deaths than heart disease in persons younger than 85 years of age. Further progress can be accelerated by applying existing cancer control knowledge across all segments of the population and by supporting new discoveries in cancer prevention, early detection, and treatment. CA Cancer J Clin 2009. © 2009 American Cancer Society, Inc.
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A. SPATHIS, J. GEORGOULAKIS, P. FOUKAS, M. KEFALA, K. LEVENTAKOS, A. MACHAIRAS, I. PANAYIOTIDES, and P. KARAKITSOS KRAS and BRAF Mutation Analysis from Liquid-based Cytology Brushings of Colorectal Carcinoma in Comparison with Formalin-fixed, Paraffin-embedded Tissue Anticancer Res, June 1, 2010; 30(6): 1969 - 1975. [Abstract] [Full Text] [PDF]
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F. LUMACHI, S. M. M. BASSO, M. BONAMINI, B. MARZANO, E. MILAN, B. U. WACLAW, and G. B. CHIARA Relationship between Preoperative Serum Markers CA 15-3 and CEA and Relapse of the Disease in Elderly (>65 years) Women with Breast Cancer Anticancer Res, June 1, 2010; 30(6): 2331 - 2334. [Abstract] [Full Text] [PDF]
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J. SZKANDERA, G. KNECHTEL, M. STOTZ, G. HOFMANN, U. LANGSENLEHNER, P. KRIPPL, T. LANGSENLEHNER, D. DEHCHAMANI, H. SAMONIGG, W. RENNER, et al. Association of Hypoxia-inducible Factor 1-alpha Gene Polymorphisms and Colorectal Cancer Prognosis Anticancer Res, June 1, 2010; 30(6): 2393 - 2397. [Abstract] [Full Text] [PDF]
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E. Giovannetti, N. Funel, G. J. Peters, M. Del Chiaro, L. A. Erozenci, E. Vasile, L. G. Leon, L. E. Pollina, A. Groen, A. Falcone, et al. MicroRNA-21 in Pancreatic Cancer: Correlation with Clinical Outcome and Pharmacologic Aspects Underlying Its Role in the Modulation of Gemcitabine Activity Cancer Res., June 1, 2010; 70(11): 4528 - 4538. [Abstract] [Full Text] [PDF]
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G. Duns, E. van den Berg, I. van Duivenbode, J. Osinga, H. Hollema, R. M. W. Hofstra, and K. Kok Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma Cancer Res., June 1, 2010; 70(11): 4287 - 4291. [Abstract] [Full Text] [PDF]
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V. G. Vogel, J. P. Costantino, D. L. Wickerham, W. M. Cronin, R. S. Cecchini, J. N. Atkins, T. B. Bevers, L. Fehrenbacher, E. R. Pajon, J. L. Wade III, et al. Update of the National Surgical Adjuvant Breast and Bowel Project Study of Tamoxifen and Raloxifene (STAR) P-2 Trial: Preventing Breast Cancer Cancer Prevention Research, June 1, 2010; 3(6): 696 - 706. [Abstract] [Full Text] [PDF]
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J. M. Siegfried Early Changes in Pulmonary Gene Expression following Tobacco Exposure Shed Light on the Role of Estrogen Metabolism in Lung Carcinogenesis Cancer Prevention Research, June 1, 2010; 3(6): 692 - 695. [Abstract] [Full Text] [PDF]
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R. Stone II, A. L. Sabichi, J. Gill, I.-l. Lee, P. Adegboyega, M. S. Dai, R. Loganantharaj, M. Trutschl, U. Cvek, and J. L. Clifford Identification of Genes Correlated with Early-Stage Bladder Cancer Progression Cancer Prevention Research, June 1, 2010; 3(6): 776 - 786. [Abstract] [Full Text] [PDF]
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Y. Dai and D. W. Siemann BMS-777607, a Small-Molecule Met Kinase Inhibitor, Suppresses Hepatocyte Growth Factor-Stimulated Prostate Cancer Metastatic Phenotype In vitro Mol. Cancer Ther., June 1, 2010; 9(6): 1554 - 1561. [Abstract] [Full Text] [PDF]
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J.-Z. Tang, X.-J. Kong, J. Kang, G. C. Fielder, M. Steiner, J. K. Perry, Z.-S. Wu, Z. Yin, T. Zhu, D.-X. Liu, et al. Artemin-Stimulated Progression of Human Non-Small Cell Lung Carcinoma Is Mediated by BCL2 Mol. Cancer Ther., June 1, 2010; 9(6): 1697 - 1708. [Abstract] [Full Text] [PDF]
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C. G. Broustas, J. S. Ross, Q. Yang, C. E. Sheehan, R. Riggins, A.-M. Noone, B. R. Haddad, F. Seillier-Moiseiwitsch, B. V. S. Kallakury, B. G. Haffty, et al. The Proapoptotic Molecule BLID Interacts with Bcl-XL and Its Downregulation in Breast Cancer Correlates with Poor Disease-Free and Overall Survival Clin. Cancer Res., June 1, 2010; 16(11): 2939 - 2948. [Abstract] [Full Text] [PDF]
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J. J. Tentler, E. L. Bradshaw-Pierce, N. J. Serkova, K. M. Hasebroock, T. M. Pitts, J. R. Diamond, G. C. Fletcher, M. R. Bray, and S. G. Eckhardt Assessment of the In vivo Antitumor Effects of ENMD-2076, a Novel Multitargeted Kinase Inhibitor, against Primary and Cell Line-Derived Human Colorectal Cancer Xenograft Models Clin. Cancer Res., June 1, 2010; 16(11): 2989 - 2998. [Abstract] [Full Text] [PDF]
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M. Bendandi, S. Marillonnet, R. Kandzia, F. Thieme, A. Nickstadt, S. Herz, R. Frode, S. Inoges, A. Lopez-Diaz de Cerio, E. Soria, et al. Rapid, high-yield production in plants of individualized idiotype vaccines for non-Hodgkin's lymphoma Ann. Onc., May 21, 2010; (2010) mdq256v1. [Abstract] [Full Text] [PDF]
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W. Y. Cheung, B. A. Neville, and C. C. Earle Associations Among Cancer Survivorship Discussions, Patient and Physician Expectations, and Receipt of Follow-Up Care J. Clin. Oncol., May 20, 2010; 28(15): 2577 - 2583. [Abstract] [Full Text] [PDF]
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P. C. Fong, T. A. Yap, D. S. Boss, C. P. Carden, M. Mergui-Roelvink, C. Gourley, J. De Greve, J. Lubinski, S. Shanley, C. Messiou, et al. Poly(ADP)-Ribose Polymerase Inhibition: Frequent Durable Responses in BRCA Carrier Ovarian Cancer Correlating With Platinum-Free Interval J. Clin. Oncol., May 20, 2010; 28(15): 2512 - 2519. [Abstract] [Full Text] [PDF]
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D. G. Pfister, B. R. Cassileth, G. E. Deng, K. S. Yeung, J. S. Lee, D. Garrity, A. Cronin, N. Lee, D. Kraus, A. R. Shaha, et al. Acupuncture for Pain and Dysfunction After Neck Dissection: Results of a Randomized Controlled Trial J. Clin. Oncol., May 20, 2010; 28(15): 2565 - 2570. [Abstract] [Full Text] [PDF]
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L. Hernandez, S. C. Hsu, B. Davidson, M. J. Birrer, E. C. Kohn, and C. M. Annunziata Activation of NF-{kappa}B Signaling by Inhibitor of NF-{kappa}B Kinase {beta} Increases Aggressiveness of Ovarian Cancer Cancer Res., May 15, 2010; 70(10): 4005 - 4014. [Abstract] [Full Text] [PDF]
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E. Blanco, E. A. Bey, C. Khemtong, S. G. Yang, J. Setti-Guthi, H. Chen, C. W. Kessinger, K. A. Carnevale, W. G. Bornmann, D. A. Boothman, et al. {beta}-Lapachone Micellar Nanotherapeutics for Non-Small Cell Lung Cancer Therapy Cancer Res., May 15, 2010; 70(10): 3896 - 3904. [Abstract] [Full Text] [PDF]
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 C. C. Chu, R. Catera, L. Zhang, S. Didier, B. M. Agagnina, R. N. Damle, M. S. Kaufman, J. E. Kolitz, S. L. Allen, K. R. Rai, et al. Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin Blood, May 13, 2010; 115(19): 3907 - 3915. [Abstract] [Full Text] [PDF]
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 M. A. Liss, M. Schlicht, A. Degueme, M. Hessner, and M. W. Datta Use of Cross Species Genomic Profiling Identifies Pathways and Genes Differentially Regulated in Prostate Cancer Cells Treated with Soy Protein Isolates or Purified Genistein Cancer Genomics Proteomics, May 1, 2010; 7(3): 111 - 128. [Abstract] [Full Text] [PDF]
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R. M. Tuttle, D. W. Ball, D. Byrd, G. H. Daniels, R. A. Dilawari, G. M. Doherty, Q. Y. Duh, H. Ehya, W. B. Farrar, R. I. Haddad, et al. Medullary Carcinoma J Natl Compr Canc Netw, May 1, 2010; 8(5): 512 - 530. [Abstract] [Full Text] [PDF]
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 M. P. Rethman, W. Carpenter, E. E. W. Cohen, J. Epstein, C. A. Evans, C. M. Flaitz, F. J. Graham, P. P. Hujoel, J. R. Kalmar, W. M. Koch, et al. Evidence-Based Clinical Recommendations Regarding Screening for Oral Squamous Cell Carcinomas J Am Dent Assoc, May 1, 2010; 141(5): 509 - 520. [Abstract] [Full Text] [PDF]
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E. Hawk and S. Patterson Modelling a dream: the molecular prevention of pancreatic cancer Gut, May 1, 2010; 59(5): 566 - 568. [Full Text] [PDF]
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