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ABOUT THE COVER: Cover images represent local therapies for treatment of metastases–percutaneous insertion of an electrode for radiofrequency ablation (upper left), beam arrangements for stereotactic body radiotherapy (lower left), and surgical resection of a liver metastasis (right). Upper left and lower left images courtesy of Robert D. Timmerman, MD, University of Texas Southwestern Medical Center, Dallas, TX. Right image courtesy of Roderich E. Schwarz, MD, PhD, University of Texas Southwestern Medical Center, Dallas, TX.